Thursday, August 4, 2016

Researchers inhibit tumor growth in new subtype of lung cancer

Lung cancer is the most common cause of cancer deaths, accounting for about a third of all tumor-related deaths. Adenocarcinomas, a non-small cell lung cancer (NSCLC), account for about 40 percent of cancer diagnoses, but few treatments are available for the disease.
A team of investigators led by Elena Levantini, PhD, a research associate in Hematology-Oncology at Beth Israel Deaconess Medical Center (BIDMC), instructor of medicine at Harvard Medical School and a member of the Harvard Stem Cell Institute, have identified a subtype of human adenocarcinoma. The research could help determine which individuals are at greatest risk of developing lung tumors that may be amenable to a new therapy to inhibit their progression. The results -- done in collaboration with the Cancer Science Institute at the National University of Singapore (CSI NUS) -- were published today in the journal Science Translational Medicine.
"Advances in lung cancer therapy require a greater understanding of the molecular origins of this deadly disease," said last corresponding author Levantini, who is also a researcher at the Institute of Biomedical Technologies at the Italian National Research Council (ITB-CNR). "Understanding the differences among lung cancers also could lead to innovations in treatment strategies and allow us to overcome drug-resistance, relapse and disease progression."
Levantini and colleagues previously showed that NSCLC tumor cells frequently express too little or none of a transcription factor called C/EBPα, a protein that regulates gene expression and cell proliferation in lung tissues. It's also known to play a role in a form of leukemia, as well as liver cancer, squamous cell skin carcinomas, squamous cell cancers of the head and neck and other cancers. In their previous work, the scientists suspected that C/EBPα may act as a tumor suppressant in normal cells, but the mechanism by which its absence promoted lung cancer tumors remained unclear.
In a series of in vitro experiments, the researchers demonstrated that C/EBPα indeed works as a tumor suppressant by restraining the expression of another molecule known to play a role in triggering and maintaining tumor growth. This molecule, called BMI1, is an oncogenic protein that has been implicated in colon cancer, a form of leukemia and breast and gastric cancers.
To determine the relationship between the suspected tumor suppressor (C/EBPα) and the oncogenic protein (BMI1), the researchers first altered a line of human adenocarcinoma cells to overexpress C/EBPα. That led to a marked reduction in the expression of BMI1. When the team analyzed tissues from 261 patients with NSCLC, they found an inverse correlation between the two molecules; that is, more than 80 percent of patient tissues with low levels of the tumor suppressing C/EBPα were positive for BMI1 expression. Likewise, an analysis tissue samples from patients with lung adenocarcinoma with no or low C/EBPα expression revealed that those with lower levels of BMI1 were more likely to survive, a pattern that has prognostic value, the researchers wrote.
"Our findings suggest that the lung cancer subtype defined by the loss of C/EBPα expression might specifically benefit from therapies that inhibit BMI1," the scientists wrote. "Thus, identifying factors that modulate its expression has generated major clinical interest."
The research team was also able to validate its findings in mice. In one set of experiments with mice engineered to express no C/EBPα, the scientists found an inverse relationship between the transcription factor and BMI1 that was nearly identical to its data from human adenocarcinoma. By manipulating BMI1 expression in vivo, the researchers were also able to confirm that decreasing the expression of the oncogenic protein was enough to fully inhibit tumor formation and even significantly arrest tumor growth.
"BMI1 plays a substantial role in many solid tumors, including one of the most aggressive models of lung cancer, and its expression is linked with tumor growth, invasion, metastasis, prognosis and recurrence," Levantini said. "Our findings could help us design better therapies for the subset of adenocarcinoma patients with low C/EBPα and high BMI1 expression pattern."
Study coauthors include first author Kol Jia Yong, Henry Yang, Bhavin M. Thakkar, Ross A Soo and co-corresponding author Daniel G. Tenen, all of the CSI NUS; BIDMC investigators Daniela S. Basseres, Robert S. Welner, Wen Cai Zhang, Meritxell Alberich-Jorda, Junyan Zhang, Lorena Lobo de Figueiredo-Pontes, Chiara Battelli, Christopher J. Hetherington, Min Ye, Hong Zhang, Karen O'Brien, Olivier Kocher, Pu Zhang and Bing Lim; Benedict Yan; Giorgia Maroni; Maria Cristina Magli; Alain C. Borczuk; Lyuba Varticovski; Young-Choon Moon; Nadiya Sydorenko; Liangxian Cao; and Thomas W. Davis; Atsushi Iwama; Balazs Halmos and Donna Neuberg. For a full list of contributors and their institutions, please see the full article online.
This work was funded by National Institutes of Health and National Cancer Institute (NIH/NCI P50 CA90578) Project 2 grant; the NCIS Yong Siew Yoon Research Grant through donations from the Yong Loo Lin Trust, the Singapore Ministry of Health's National Medical Research Council under its Singapore Translational Research (STaR) Investigator Award, and by the National Research Foundation of Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative; FAMRI YCSA initiative; FAMRI YCSA 052409 and FAMRI CIA 103063, FAMRI YCSA 072165, Doctor's Cancer Foundation Award, IASLC Award, MIUR Flagship Interomics Project and MSMT Navrat grant LK21307. Researchers were supported by José Carreras fellowship, FIJC-10; NCI T32/K12/R25 award; the Agency for Science, Technology and Research (A*STAR), Singapore; the National Medical Research Council of Singapore (NMRC/CG/NCIS/2010) and the DF/HCC Cancer Center Support Grant 5P30 CA006516.

Story Source:
The above post is reprinted from materials provided by Beth Israel Deaconess Medical Center. Note: Materials may be edited for content and length.

Journal Reference:
  1. K. J. Yong, D. S. Basseres, R. S. Welner, W. C. Zhang, H. Yang, B. Yan, M. Alberich-Jorda, J. Zhang, L. L. de Figueiredo-Pontes, C. Battelli, C. J. Hetherington, M. Ye, H. Zhang, G. Maroni, K. OBrien, M. C. Magli, A. C. Borczuk, L. Varticovski, O. Kocher, P. Zhang, Y.-C. Moon, N. Sydorenko, L. Cao, T. W. Davis, B. M. Thakkar, R. A. Soo, A. Iwama, B. Lim, B. Halmos, D. Neuberg, D. G. Tenen, E. Levantini. Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression. Science Translational Medicine, 2016; 8 (350): 350ra104 DOI: 10.1126/scitranslmed.aad6066

Next steps towards preventing cancer and Alzheimer's

A new generation of drugs that prevent cancer and Alzheimer's could be developed, thanks to research from the University of Warwick.
Dr Ioannis Nezis at the School of Life Sciences has led a research team to identify, and create a database of, the proteins needed for an essential cellular process, autophagy, which keeps our bodies healthy, but which declines as we age.
Better understanding of how these proteins work could lead to the development of drugs to stop this decline, and keep cells healthy for longer -- thus preventing major age-related conditions, such as cancer, Crohn's disease, neurodegenerative conditions, as well as viral and bacterial infections.
Dr Nezis' research team has identified over 700 previously undiscovered proteins that are related to autophagy, and has created a database containing them. This will enable the scientific community to experiment and find ways to activate autophagy inside human cells.
Autophagy is an essential process, during which our cells consume and destroy any parts of themselves which are harmful or damaged, and which could cause serious illnesses if left alone. This cellular process naturally declines as we age, so that humans are less able to eject harmful infections and mutations, leaving us more prone to illness and degeneration.
Dr Nezis explained how this research could impact the pharmaceutical world: "Our novel database resource will open a lot of new avenues in basic and translational science. Identifying novel selective autophagy-related proteins will help for the development of novel pharmaceutical drug targets for a large variety of diseases like cancer, neurodegeneration and other ageing-related diseases, infections, diabetes, obesity and Crohn's disease."
"Importantly, understanding the molecular mechanisms of selective autophagy will help researchers to find interventions to activate the autophagic pathway to prevent ageing and promote healthy well-being during the life course," Dr Nezis continued.
The School of Life Sciences at the University of Warwick is a pioneer of key research in this field.
As well as creating this crucial database of autophagy-related proteins, the laboratory here founded the Autophagy UK Network, a group dedicated to bringing together experts of this cellular process from across the country.

Story Source:
The above post is reprinted from materials provided by University of Warwick. Note: Materials may be edited for content and length.

Journal Reference:
  1. Anne-Claire Jacomin, Siva Samavedam, Vasilis Promponas, Ioannis P. Nezis. iLIR database: a web resource for LIR motif-containing proteins in eukaryotes. Autophagy, 2016; 00 DOI:10.1080/15548627.2016.1207016

Monday, August 1, 2016

SHOULD YOU PARK YOUR CARBS?

Don’t fear breads, pasta and sugars. Here’s how to use this macronutrient to advance your muscle-building and fat-burning goals.



Protein gets all the glory when it comes to building muscle mass, and carbohydrates get all the blame when we talk about excess bodyfat. But the truth is, you need carbs to support muscle building, provide energy to fuel workouts and replenish the glycogen you burn during them. In fact, you also need a certain amount of carbs to help you lose bodyfat as readily as possible. If you cut carbs too low for too long when trying to drop bodyfat, you force your body to convert dietary protein and possibly even muscle tissue into energy. That works against your goal of maintaining and building muscle while following a fat-loss program.
Understanding what carbs are and how they function in your diet regimen is crucial if you want to get the most from advanced dietary techniques that involve carbohydrate manipulation. Regardless of your level of development as a bodybuilder, you must assess many variables to determine what you need and when. First you need to have a reasonable goal, such as losing bodyfat while maintaining muscle mass. In a perfect world, it would be great to lose bodyfat and add an equivalent amount of muscle, but that isn’t realistic for most people.
Second, it’s important to know that different types of carbs are digested at different rates and that they have various effects on insulin release and metabolism. You must also understand how other foods and macronutrients play a role in the way carbs impact your metabolism. Finally, MMI describes how different carb strategies can help you get the most from your nutrition program.
To help us explain all you need to know about this very basic yet complicated macronutrient, MuscleMag turns to author and sports nutrition researcher Jonathan Mike, PhD(c), CSCS, NSCA-CPT, USAW. Here’s what he had to say about how carbs relate to the bodybuilder and athlete.

PART I: THE BASICS

Before you implement a carb strategy in your bodybuilding nutrition program, it’s helpful to understand what carbs are and what they do.

FAQ: WHAT ARE CARBOHYDRATES?

“Carbohydrates are one of the four major classes of organic compounds in living cells. The term ‘carbohydrate’ refers to saccharides, sugars and their derivatives,” explains Mike. Simple sugar molecules called monosaccharides include glucose, one of the most important forms of energy in living organisms. Disaccharides are carbohydrate molecules consisting of two monosaccharides. The most common of these is sucrose (table sugar), made up of a glucose and fructose molecule.
“Polysaccharides may be composed of up to hundreds of thousands of monosaccharides joined together,” Mike says. These include starch, cellulose and glycogen, and they serve many functions including storage and structural support. Some of these polysaccharides are digestible by humans, meaning they can be absorbed and used for energy. Others like insoluble fiber aren’t, even though they play crucial roles in the body despite the fact that they don’t “enter” it.

FAQ: WHAT’S THE PURPOSE OF CARBS IN A DIET?

“Carbs are actually required for the complete metabolism of fatty acids,” Mike says. This means you must consume 50–100 grams of carbs per day to prevent ketosis, a metabolic acidosis that results from an accumulation of ketone bodies after excessive fat metabolism. This minimal amount of carbs equates to about 3–5 pieces of bread per day. Beyond this, the primary role of carbs in the body is to provide fuel for energy. “The amount of carbs needed by individuals and athletes depends on their total energy requirement, including expenditure,” adds Mike.

FAQ: WHAT’S THE PURPOSE OF CARBS IN AN ATHLETE’S OR BODYBUILDER’S DIET?

While athletes and bodybuilders have greater energy needs than sedentary people, this macronutrient plays different roles depending on your goal or needs. “The amount and purpose of carbs depends on the individual’s training schedule, volume of training, intensity, frequency of training and type of competition,” Mike says. This includes strength vs. endurance sports, as well as adjusting carb intake for bodybuilding needs (growth vs. cutting phases). “For mass building, increasing carbs helps boost overall caloric intake and replenish glycogen stores,” Mike explains. Glycogen is the stored form of carbs found in muscle tissue and the liver that helps fuel training. Having plenty of glycogen not only helps build muscle mass but can also boost strength and power.
“In addition, taking in carbs during exercise helps sustain blood glucose levels while sparing glycogen and helping stave off catabolism [muscle breakdown],” says Mike. There’s no one-size-fits-all approach in determining how many carbs you should consume to spare glycogen during weight workouts. Muscle-Mag’s guidelines below are designed for the average bodybuilder.

FAQ: WE HEAR A LOT OF DIFFERENT TERMS FOR VARIOUS TYPES OF CARBS. WHAT’S THE BEST WAY TO CATEGORIZE THEM?

Foods are called “slow” or “fast” digesting, and this is crucial when it comes to carbs. “This has to do with the glycemic index [GI],” Mike explains. Foods with a GI score of 70 or higher are considered to have a high GI value; those below 55 are considered low on the GI. While this distinction may have merit when consuming these foods on their own, it’s often irrelevant when you mix in other foods high in fiber and fats, which reduce the insulin impact of high-GI foods.
To sum up: The best way to view carbohydrates is in the context of eating them alone or with other foods. When you want fast-acting carbs, eat these sources alone or with protein such as whey. When you want to slow the action of carbs, add fats and fiber to your meal. Some fast-digesting carbs include table sugar, honey, white rice, rice cakes and white bread. Some slow-digesting carb sources are yams, oatmeal, brown rice, and vegetables such as broccoli, cabbage and spinach.

FAQ: WHY ARE CARBS CONSIDERED AN ANABOLIC NUTRIENT?

“Good question,” Mike says. “Carbs cause an insulin release, which plays a crucial role in the metabolism of all macronutrients. You certainly need carbs for muscle building, but the issue is timing.” Our bodies have a unique ability to switch fuel sources for exercise and after exercise, called metabolic flexibility. They shift from fats to carbs and from carbs back to fats depending on the cues we send it. “For instance, as exercise intensity increases, your body shifts to more carb metabolism; after exercise the shift occurs back to more fat metabolism,” Mike explains.
The key word here is “intensity,” and here’s how it works: Around workout time, glucose transporters move to the surface of muscle cells and begin “pumping” glucose into them. Insulin also signals these muscle cells to shift to carbohydrate metabolism. “The energy status of these cells plays a large role in what happens within them,” Mike says. In other words, if your muscle cells are low on glucose and/or muscle glycogen, they’ll start using incoming glucose from your carb/protein shake (circulating blood glucose) for fuel and use any additional glucose to create muscle glycogen. “Furthermore, insulin will also stimulate an increased uptake of fatty acids into muscle cells,” Mike says. The end result is that you’ll use fat to build muscle tissue.
After workouts, insulin continues to drive anabolism. “At this point, insulin’s primary impact is believed to be helping your body push through catabolism more quickly,” Mike explains. This reduces the trauma caused by exercise and increases the muscle-building benefits of your workouts.

FAQ: WHY DOES INSULIN INCREASE BODY FAT IF IT’S ANABOLIC?

“If your muscle cells are already full of glucose and glycogen and are topped off with intramuscular triglycerides [fats], insulin signaling will continue to operate in a low-energy state but will also turn excess glucose into [body]fat,” Mike explains. This is most likely to happen at times of day when you aren’t training or refueling from training.
So, consuming a fast-digesting carb-and-protein combo after workouts is best for maximizing protein synthesis. At other times of day, avoid fast-digesting carbs (sugars) because they’re more likely to be stored as bodyfat and less likely to support muscle building.

PART II: DAILY CARB INTAKE 

In this section, we boils it all down to easy-to-follow charts, demonstrating how to adjust your carbohydrate intake to get the most from your training and nutrition programs to achieve your goals.

FAQ: WHEN YOU’RE TRYING TO GROW DURING THE OFFSEASON, WHAT TYPE OF CARBS SHOULD YOU EAT AND WHEN? HOW MANY SHOULD YOU CONSUME PER DAY?

“The answer to this question depends on many factors, including lifestyle, training volume and intensity, workout schedule, and routines and splits,” Mike says. Those who follow moderate and high-volume training protocols need greater amounts of both carbs and protein in their nutrition programs to meet their body’s needs.
“Consuming Carbs for Offseason Muscle Gain” addresses the daily needs of a 180-pound male bodybuilder emphasizing muscle building while trying to keep bodyfat somewhat in check.

FAQ: WHEN YOU’RE TRYING TO SHED BODYFAT, HOW SHOULD YOU ADJUST YOUR CARB INTAKE? WHAT SHOULD YOU TAKE IN THROUGHOUT THE DAY?

“First, I recommend taking away a few hundred calories per day,” Mike says. “I would replace half of the calories you cut from carbs with fat calories.” For example, if you eliminate 1,000 calories from carbs, replace that with up to 500 calories from dietary fats. You’ll still create a deficit of 400–500 calories per day. “When you work under your baseline calories, then macronutrient ratios become much more important,” adds Mike.
“Consuming Carbs to Reduce Bodyfat” addresses the needs of a 180-pound male bodybuilder emphasizing cutting bodyfat while trying to maintain muscle mass. Note that daily carb consumption is about half compared to a muscle-building plan.

PART III: ADVANCED STRATEGIES 

We provide a baseline plan for carb consumption when you want to build muscle mass or reduce bodyfat. But you may also want to implement more advanced carbohydrate strategies, or better understand how and why carbs work. Here are a few advanced topics.

FAQ: HOW CAN I IMPLEMENT CARB ROTATING TO BURN MORE BODY FAT?

Carb rotation, or carb cycling, has gained popularity in recent years. “It appears to be a good strategy used by bodybuilders and physique competitors for both getting contest-ready and staying lean while adding lean mass, and it’s a decent strategy for fat loss,” Mike says.
Here are some bullet points to consider:
• Very low-carb days. Get your carbs from fruits and vegetables, typically about 50 grams per day.
• Low-carb days. These days are high in protein and fat, with most of your carbs coming from vegetables and small amounts of fruits. Around workouts, take in fast-digesting carbs to help replenish glycogen. Total carb intake is about 100 grams per day.
• High-carb days. On these days you consume 400–800 grams of carbs. “The purpose is to replenish your body’s glycogen stores, stimulate an anabolic response through insulin release and allow for some relief from all the restriction,” Mike says.
Follow the five-day rotation in “Cycling Your Carbs” when you want to try a carb-rotation program.

FAQ: WHEN SHOULD I IMPLEMENT A HIGH-CARB DAY?

If you’re following a traditional low-to-moderate carb program to reduce bodyfat, you can benefit from a high-carb day without the complexity of the more restrictive carb-rotation plan. On an average day, you should consume 1–1.25 grams of carbs per pound of bodyweight, or 180–225 grams for a 180-pounder. Then, during one meal a week, boost your carbs significantly for one meal only. Take in as many carbs as you want or can, 250–400 grams worth, emphasizing starches and fast-digesting sources such as sugar. At this meal, try to keep fat intake in check to get a greater insulin response.
At other times during the week, consume more dietary fats in an effort to keep carbs and your insulin response in check. “For some reason, many people are consumed with the notion that dietary fat is evil,” Mike says. “But I don’t think it’s wise to consume low amounts of dietary fats.” Recent research bears this out. Diets with 15% or fewer calories from fats are known to decrease testosterone production, which can affect metabolism and muscle development. “Low-fat diets may also impair the absorption of fat-soluble vitamins,” Mike adds. He recommends consuming 30%–35% of calories from dietary fats on a typical day. This includes saturated fats, in about a 1:1 ratio with healthy fats.

FAQ: IS DIETARY FIBER IMPORTANT TO A BODYBUILDER SINCE IT CAN SLOW DIGESTION AND MAKE YOU FEEL FULL WHEN YOU’RE TRYING TO GET IN A LOT OF CALORIES AND MEALS?

It’s surprising how many bodybuilders overlook the dietary impact of fiber. Avoid fiber before and after workouts, but consume it at other times of day in larger quantities than bodybuilders typically do. “Fiber is incredibly important, and often underrated and undervalued by most Americans,” Mike says. Fiber holds considerable water and provides bulk to food residues in the GI tract. It exerts a “scraping” action on the cells of the gut wall, enhancing your ability to absorb nutrients. Fiber also binds to and dilutes harmful chemicals, inhibiting their activity and preventing them from entering your body.
“Many people, even strength athletes, are deficient in fiber,” Mike warns. He suggests that adult men consume about 40 grams of fiber daily, and 25 grams for women. “It’s very obvious, based on how people look these days, that most don’t even get close to this,” he says. His recommendation is based on an average diet of 2,000–2,500 calories per day. Bodybuilders consuming 3,000 or more calories daily should consume about 60 grams of fiber. Good sources include whole grains and whole-grain products, fruits, vegetables, seeds, nuts, beans and legumes.

DIET SWEETENERS VS. SUGAR 

Are these no-calorie sweeteners a good carb substitute when trying to reduce bodyfat?
“This is a complicated issue,” says Jonathan Mike, PhD(c), CSCS, NSCA-CPT, USAW. “Sugar substitutes duplicate the effect of sugar in taste, but they usually have little or no food energy.” Some are natural and some are artificial, and they’re up to 200 times sweeter than sugar. Obviously, the biggest benefit in using sugar substitutes is that they help significantly reduce calorie and carbohydrate intake.
However, there is a downside. “I’ve some seen some research showing that, rather than promoting weight loss, the use of diet drinks is a marker for increasing weight gain and obesity,” Mike says. Study participants who consumed diet soda were more likely to gain weight than those who drank naturally sweetened soda. While this study used non-athletes, it’s possible that bodybuilders may see less desirable results when they use diet sweeteners compared to not using them at all.
“Interestingly, a sweet taste induces an insulin response, which causes blood sugar to be stored in tissues,” Mike says. “Because blood glucose doesn’t increase with artificial sweeteners, this may cause hypoglycemia [low blood sugar] and increased food intake.” In other words, we continue to crave sweets, consuming food until the craving is met.
Bottom line: If you use sugar substitutes while cutting carbs, make sure to ingest them with other foods to help mitigate cravings.

WONDERING IF YOU SHOULD TRY THE KETOGENTIC DIET? READ THIS.

Fat is bad for you.” That’s what we’ve been told for generations. So it’s easy to question why there are so many people talking about the ketogenic diet, which is basically a high-fat, moderate-protein and ultra-low-carb diet. In other words, it’s a diet that encourages you to eat butter, cheese and bacon. … How exactly is this “healthy?” It all comes down to how your body metabolizes fat. The ketogenic diet triggers what’s called “ketosis” — it’s when your body burns fat for energy instead of glucose. Because glucose (from carbs) is your body’s preferred fuel source, when you deny your body this fuel, it relies on its second favorite food — fat.

SHOCK YOUR METABOLISM

Ketosis won’t happen unless you take it seriously. You can stuff all the butter and bacon in your body that you want to, but if you’re still eating carbs, you’ll stay in glycolysis, which means that your body is still burning glucose and that fat isn’t going anywhere useful. One of the more effective ways to enter ketosis is to do a fast before starting the diet in order to deplete your glycogen stores. Then as soon as you fry up your first buttery, fatty breakfast, your body should start burning ketones for fuel instead of sugar. The more your body becomes accustomed to entering ketosis, the easier it gets to experience the ketogenic diet’s benefits.

THE KETO BUMP

One thing keto users report is an insane boost in energy levels. This is great news for competitive athletes because ketosis all but removes the barrier of “hitting the wall” after a couple of hours of intense workouts.
Did you also know that your brain is 60 percent fat? Lucky you, Mr. Genuis, because consuming all this extra fat on the keto diet might actually improve cognitive function. Some clinical and animal studies also show decreased instances of headaches, lowered proclivity for neurodegenerative disease and healthier sleep with more deep REM cycles, as well as cancer-resistant benefits.
Yes, that’s right, tumors have a favorite fuel source, too, and, you guessed it, it’s glucose! Studies like the one conducted at the KetoPet Sanctuary in Austin, Texas, are finding incredible results in the field of cancer treatment by starving cancer of its favorite food: carbs.

WHAT ABOUT SHREDDING/BULKING?

Shredding on keto is pretty easy — you eat fat to burn fat … but what about bulking? Yes, you can absolutely gain mass while in ketosis. If you’re systematic about the food you eat and cycle off keto once a week for 24 hours of re-feeding, you can add lean mass and remain shredded. BUT you have to be diligent; there’s no cheating. Stick with the high-fat, moderate-protein, low-carb split or your gains will be in vain.

OH, ALSO THESE OTHER GREAT BENEFITS

• When followed properly, ketogenic dieting can stabilize your blood sugar levels — making diabetes much easier to manage.
• Many people experience lower cholesterol and blood pressure on keto.
• Users experience increased satiety — meaning bye-bye hangry moods.
• You’re encouraged to add bacon, ground beef and butter back into your diet. Hell yes.
While there are some hurdles to overcome in the ketogenic diet (finding the right foods, avoiding the carb traps, etc.), once you hit ketosis and your body is craving fats for fuel, you’re already on the road to redefining the nutritional benefits of fat. So rather than cycling through the same old meal prep filled with grilled chicken, brown rice and broccoli five days a week, why not stock up on butter, bacon, meat and cheese?
Welcome back, fat, we’ve missed you.

Meat consumption contributing to global obesity

Should we be warning consumers about over-consumption of meat as well as sugar?
That's the question being raised by a team of researchers from the University of Adelaide, who say meat in the modern diet offers surplus energy, and is contributing to the prevalence of global obesity.
Comparative anatomy and human evolution experts from the University's School of Medicine have been studying the correlation between meat consumption and obesity rates in 170 countries.
"Our findings are likely to be controversial because they suggest that meat contributes to obesity prevalence worldwide at the same extent as sugar," says Professor Maciej Henneberg, head of the Biological Anthropology and Comparative Anatomy Research Unit.
"In the analysis of obesity prevalence across 170 countries, we have found that sugar availability in a nation explains 50% of obesity variation while meat availability another 50%. After correcting for differences in nations' wealth (Gross Domestic Product), calorie consumption, levels of urbanization and of physical inactivity, which are all major contributors to obesity, sugar availability remained an important factor, contributing independently 13%, while meat contributed another 13% to obesity.
"While we believe it's important that the public should be alert to the over-consumption of sugar and some fats in their diets, based on our findings we believe meat protein in the human diet is also making a significant contribution to obesity," Professor Henneberg says.
The research has been conducted by PhD student Wenpeng You, who recently presented the findings of his work at the 18th International Conference on Nutrition and Food Sciences in Zurich, Switzerland. This research has also formed the basis of two papers on the issue, published inBMC Nutrition and the Journal of Nutrition & Food Sciences.
"There is a dogma that fats and carbohydrates, especially fats, are the major factors contributing to obesity," Mr You says.
"Whether we like it or not, fats and carbohydrates in modern diets are supplying enough energy to meet our daily needs. Because meat protein is digested later than fats and carbohydrates, this makes the energy we receive from protein a surplus, which is then converted and stored as fat in the human body."
Mr You says there have been several other academic papers showing that meat consumption is related to obesity, but the authors have often argued that it's the fat content in meat that contributes to the problem. "On the contrary, we believe the protein in meat is directly contributing to obesity," Mr You says.
Professor Henneberg says: "It would be irresponsible to interpret these findings as meaning that it's okay to keep eating a diet high in fats and carbohydrates. Clearly, that is not okay, and this is a serious issue for our modern diet and human health.
"Nevertheless, it is important that we show the contribution meat protein is making to obesity so that we can better understand what is happening. In the modern world in which we live, in order to curb obesity it may make sense for dietary guidelines to advise eating less meat, as well as eating less sugar," he says.

Story Source:
The above post is reprinted from materials provided by University of Adelaide. Note: Materials may be edited for content and length.

Journal Reference:
  1. Wenpeng You, Maciej Henneberg. Meat consumption providing a surplus energy in modern diet contributes to obesity prevalence: an ecological analysis. BMC Nutrition, 2016; 2 (1) DOI:10.1186/s40795-016-0063-9

Fish oil vs. lard: Why some fat can help or hinder your diet

Consuming fish oil instead of lard makes a significant difference in brain function. New research shows that brain function remains normal and manages to restrain from eating more than necessary when this type of fat is consumed.
Credit: © colnihko / Fotolia
A diet high in saturated fat can make your brain struggle to control what you eat, says a new study in Frontiers in Cellular Neuroscience.
If people are looking to lose weight, stay clear of saturated fat. Consuming these types of fatty food affects a part of the brain called the hypothalamus, which helps regulate hunger.
The fat causes inflammation that impedes the brain to control the food intake. In other words, people struggle to control how much they eat, when to stop and what type of food to eat -- symptoms seen in obesity.
The study found, through tests in rats, that a meal rich in saturated fat, reduces a person's cognitive function that make it more difficult to control eating habits.
"These days, great attention is dedicated to the influence of the diet on people's wellbeing. Although the effects of high fat diet on metabolism have been widely studied, little is known about the effects on the brain;" explained Professor Marianna Crispino and Professor Maria Pina Mollica from the University of Naples Federico II.
A diet rich in fat can take different forms and in fact, there are different types of fats. Saturated fats are found in lard, butter or fried food. Unsaturated fats are rich in food such as fish, avocado or olive oil.
Consuming fish oil instead of lard makes a significant difference. The research shows that brain function remains normal and manages to restrain from eating more than necessary.
"The difference was very clear and we were amazed to establish the impact of a fatty diet onto the brain. Our results suggest that being more aware about the type of fat consumed with the diet may reduce the risk of obesity and prevent several metabolic diseases," concludes Professor Crispino.

Story Source:
The above post is reprinted from materials provided by Frontiers. Note: Materials may be edited for content and length.

Journal Reference:
  1. Emanuela Viggiano, Maria Pina Mollica, Lillà Lionetti, Gina Cavaliere, Giovanna Trinchese, Chiara De Filippo, Sergio Chieffi, Marcello Gaita, Antonio Barletta, Bruno De Luca, Marianna Crispino, Marcellino Monda.Effects of an High-Fat Diet Enriched in Lard or in Fish Oil on the Hypothalamic Amp-Activated Protein Kinase and Inflammatory Mediators. Frontiers in Cellular Neuroscience, 2016; 10 DOI:10.3389/fncel.2016.00150

An hour of moderate exercise a day enough to counter health risks from prolonged sitting

The health risks associated with sitting for eight or more hours a day -- whether at work, home or commuting -- can be eliminated with an hour or more of physical activity a day, according to a study from an international team of researchers.
Ever since a study back in 1953 discovered that London bus drivers were at greater risk of heart disease compared to bus conductors, scientists have found increasing evidence that lack of physical activity is a major risk factor for several diseases and for risk of early death. Recent estimates suggest that more than 5 million people die globally each year as a result of failing to meet recommended daily activity levels.
Studies in high-income countries have suggested that adults spend the majority of their waking hours sitting down. A typical day for many people is driving to work, sitting in an office, driving home and watching TV. Current physical activity guidelines recommend that adults do at least 150 minutes of moderate intensity exercise per week.
In an analysis published today in The Lancet that draws together a number of existing studies, an international team of researchers asked the question: if an individual is active enough, can this reduce, or even eliminate, the increased risk of early death associated with sitting down?
In total the researchers analysed 16 studies, which included data from more than one million men and women. The team grouped individuals into four quartiles depending on their level of moderate intensity physical activity, ranging from less than 5 minutes per day in the bottom group to over 60 minutes in the top. Moderate intensity exercise was defined as equating to walking at 3.5 miles/hour or cycling at 10 miles/hour, for example.
The researchers found that 60 to 75 minutes of moderate intensity exercise per day were sufficient to eliminate the increased risk of early death associated with sitting for over eight hours per day. However, as many as three out of four people in the study failed to reach this level of daily activity.
The greatest risk of early death was for those individuals who were physically inactive, regardless of the amount of time sitting -- they were between 28% and 59% more likely to die early compared with those who were in the most active quartile -- a similar risk to that associated with smoking and obesity. In other words, lack of physical activity is a greater health risk than prolonged sitting.
"There has been a lot of concern about the health risks associated with today's more sedentary lifestyles," says Professor Ulf Ekelund from the Medical Research Council Epidemiology Unit at the University of Cambridge. "Our message is a positive one: it is possible to reduce -- or even eliminate -- these risks if we are active enough, even without having to take up sports or go to the gym.
"For many people who commute to work and have office-based jobs, there is no way to escape sitting for prolonged periods of time. For these people in particular, we cannot stress enough the importance of getting exercise, whether it's getting out for a walk at lunchtime, going for a run in the morning or cycling to work. An hour of physical activity per day is the ideal, but if this is unmanageable, then at least doing some exercise each day can help reduce the risk."
The researchers acknowledge that there are limitations to the data analysed, which mainly came from participants aged 45 years and older and living in western Europe, the US and Australia. However, they believe that the strengths of the analysis outweigh these limitations. Most importantly, the researchers asked all included studies to reanalyse their data in a harmonized manner, an approach that has never before been adopted for a study of this size and therefore also provides much more robust effect estimates compared with previous studies.

Story Source:
The above post is reprinted from materials provided by University of Cambridge. The original story is licensed under a Creative Commons Licence. Note: Materials may be edited for content and length.

Journal Reference:
  1. Ulf Ekelund, Jostein Steene-Johannessen, Wendy J Brown, Morten Wang Fagerland, Neville Owen, Kenneth E Powell, Adrian Bauman, I-Min Lee.Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women. The Lancet, 2016; DOI: 10.1016/S0140-6736(16)30370-1