Tuesday, October 2, 2018

Macros: What Are They and Why Do I Need Them?

Have you asked yourself, “Why are people so obsessed with these things?” Perhaps you’ve let out a sigh and dismissed them as “fads” in the fitness industry. Those leopard print leggings will go out of style before anyone can finish sipping their skinny tea, right? While that’s quite possible, it’s not necessarily true for macros (or for aerial yoga, for that matter). Talk of macros is spreading like wildfire on the internet and social media, and rightfully so. Before you get caught up counting them, it’s important to know what they are and why you need them.
“Macros” are short for macronutrients. They consist of three food categories: carbohydrates, fats and proteins. Each system in your body depends on the availability of these three macronutrients. Macronutrients affect things like body composition, appetite, satiety, likelihood of disease and its progression, perceived energy levels and your ability to recover from exercise. We’re going to talk more about the role of each, along with recommended food choices.

Carbohydrates

Carbohydrates are the brain and central nervous system’s primary choice of fuel. When carb intake is low, brain fog and a decrease in athletic performance may result. The Dietary Guidelines Advisory Committee suggests a minimum intake of 130 grams per day to meet basic energy needs to sustain bodily systems. However, your total carb intake will vary based on activity levels, goals, genetics and body size. In general, aim for a carb intake of 45 to 65 percent of total calories. Slow-digesting, minimally processed foods with sufficient fiber are the best choices.
• Oats
• Vegetables
• Fruits
• Barley
• Flaxseed

Fats

There are many roles fat plays throughout your body. It is the most energy-dense nutrient, and it helps manufacture and balance hormones. It also helps transport fat-soluble vitamins. Overconsumption of fat may lead to an increased risk of heart disease. This effect seems to occur when saturated fat intake is high and the diet is also high in sugar and processed carbohydrates. Excess body fat also can result from this scenario. Avoid vegetable oils rich in omega-6 such as corn oil, safflower oil, sunflower oil and cottonseed oil. Fats should make up 20 to 35 percent of your total calories.
• Walnuts
• Avocado
• Salmon
• Olive oil

Protein

Carbohydrates and fats are managed efficiently by the body. However, it’s difficult to maintain adequate protein levels without a proper diet. If your diet lacks amino acids (building blocks of protein) that your body can’t make on its own, your muscular structure, hormone levels and enzyme levels will suffer. Protein quality will vary based on a food’s level of amino acids. Animal proteins typically rank higher, while plant proteins (although they do contain all the essential amino acids) rank lower. Most healthy adults require 0.8 grams of protein per kilogram of bodyweight. Some experts suggest aiming for 1 gram of protein per pound of bodyweight, since higher amounts of protein are associated with improved immune healthy, metabolism and weight management.
• Eggs
• Cottage cheese
• Lentils
• Whey protein 
• Chicken

Probiotics For Athletes

Probiotics are all the rage today — whether they be in the form of foods naturally rich in this beneficial bacteria (such as yogurt) or specific supplements standardized to specific strengths. And with good reason, your body is home to more than 100 trillionmicroorganisms. This means that the bacteria in your body outnumber all your cells by 10 to 1!
The vast majority of these bacteria reside in your gut. About 70 percent of them represent healthy (“good”) bacteria, while the remaining 30 percent are “bad” and are detrimental to your system. The flora in your gut perform a variety of functions that are essential to your health. In fact, it’s estimated that 70 percent of your immune cells are located in your intestinal tract, making the health of your digestive system essential to overall bodily health.
Research shows that the health of the digestive system dramatically affects digestion and absorption of nutrients, immune function, skin health, cognitive ability, metabolism and even muscle mass, body composition and endurance. Probiotics help regulate the balance of microbial cells — bacteria and yeast — that exist there. An imbalance in the gut microbia can lead to diarrhea, constipation, inflammatory bowel and other gut ailments, plus numerous health ailments stemming from a compromised immune system.
Gut microbial balance is adversely affected by poor diet, infections, antibiotic treatments and other external factors. To restore this balance, ingesting live probiotic bacteria is vital. Probiotics are measured in colony-forming units (CFU), which determine how much of the bacteria can divide into colonies in your system. Typically, the higher the CFU, the more beneficial the food or supplement (to a point, which will be explained later).
Foods naturally rich in probiotic “bugs” include yogurt, kefir, raw cheese, sourdough bread and various fermented foods such as apple cider vinegar, kombucha and kvass. However, because you’d have to consume significant amounts of these foods on a daily basis to achieve adequate quantities of beneficial bacteria, supplementation via probiotic capsules, tablets or gummies is generally required for improved health.

PERFORMANCE, IMMUNITY AND BODY COMPOSITION

Athletes have extremely high nutrient requirements because of the stress of high-intensity training, competition and an overall active lifestyle. The preponderance of protein intake and high amount of carbohydrates necessary to fuel activity puts added strain on the digestive system, plus can upset microorganism balance by reducing probiotic counts. This is aggravated by sheer caloric intake, which often takes the form of fast food or similar, less-than-optimal choices. Over time, this becomes chronic and food intake doesn’t equate to nutrient absorption, which may lead to a catabolic effect on muscle tissue and can adversely affect overall performance.
Protein intake is one issue of vital importance to athletes because of its role in recovery and muscle building. Because your body can only digest about 25 grams of protein at a time, the more you are able to absorb amino acids from what you consume, the greater your anabolic growth potential. Emerging research demonstrates that probiotics play a key role in the muscle growth process and improved recovery by increasing uptake of amino acids in the small intestine. For example, the BC30 form of the probiotic spore Bacillus coagulanswas shown in research to increase protein uptake, leading to reduced muscle damage, decreased muscle soreness and improved recovery among athletes.
In addition, the athletic and fitness activities we pursue to improve our bodies and competitive performance also can have an adverse effect on immune response. For instance, an athlete can be more prone to bacterial and viral infections for up to 72 hours after training. This happens because the body is subjected to acute changes in the secretion of antibodies during intense activity.
Probiotics can help because they adhere to the gut lining and create a barrier of sorts that helps prevent the adhesion of pathogens that will make you sick. They also bolster that critical 70 percent of the immune system found in your digestive tract, which means enhanced recovery and recuperation from intense activity.
What’s worse, the sport or activity you choose can exacerbate problems in your gut. For instance, it is estimated that 30 to 60 percent of long-distance runners are impacted by gastrointestinal discomfort. Because blood flow is directed to muscles during extended running bouts, reduced blood flow in the digestive tract leads to malabsorption of food. It can be so bad that many runners are afflicted with acute diarrhea.
For all these reasons, use of daily probiotics (whether from food or supplement sources) is a proven way to improve your fitness and athletic performance. In addition, improving and maintaining immune system health is critical for long-term athletic success by maximizing recovery and minimizing lost training days because of illness or malaise.
As an added bonus, probiotic supplementation has also been shown to have a beneficial effect on body composition. In one clinical study, female athletes who consumed a specific form of the highly beneficial Bacillus subtilis probiotic (DE111) over 10 weeks postworkout with a protein drink significantly decreased body-fat percentage. In addition, they also performed better in the deadlift exercise during weight training.

WHICH ONES AND HOW MUCH?

So the evidence is clear — probiotics are key to improved athletic performance, recovery and overall health. To take full advantage of these beneficial bacteria, finding the right probiotics for your needs takes a little research. It’s not necessarily a one-size-fits-all supplement.
From the CFU standpoint, more is not always better. While supplements with 10 or 15 billion CFU are generally more powerful than ones with 5 billion, ingesting too much in supplement form can actually cause stomach upset — the exact opposite of the intended result. Experts say 50 billion is probably the maximum daily amount needed, although this might be excessive for many people.
As to which probiotics you should use, this can depend on the specific effect you’re seeking. While all of them enhance digestion and improve immune response, some are more effective than others. And several have very specific researched benefits for athletes. What follows are some popular probiotic strains and the specific sports and fitness benefits they can impart. Fortunately, multiple strains are often packaged together for greater benefit. Just be sure the benefits you’re seeking can be matched to the probiotics (and adequate CFU count) in the products you purchase.
TOP PROBIOTICS FOR ATHLETES
Lactobacillus acidophilus. This is the most researched and proven probiotic, having been the subject of thousands of studies. It provides many benefits, including digestive health and pH balance, improvements in blood pressure and production of enzymes that help in milk digestion. It is also critical in nutrient absorption, immune response and the ability to fight bacterial, fungal and viral infections.
Lactobacillus rhamnosus. This probiotic helps to inhibit bacterial infections. One patented strain of rhamnosus known as Lactobacillus gg is best known for stimulating the immune system, fighting allergies, reducing systemic inflammation and improving blood sugar control.
Lactobacillus plantarum. This bug has been shown to increase iron absorption and improve iron levels. It also has a powerful effect on the immune system and can help reduce the risk of acquiring the common cold. Better yet, research suggests it may help you decrease bodyweight and build muscle mass in as little as six weeks of consistent use. Finally, this bug was shown in a clinical study to increase physical endurance, especially when exercising in heat.
Lactobacillus helveticus. Because it can improve sleep quality and duration, this probiotic is beneficial for recovery for hard training athletes. It is also shown in studies to reduce blood pressure and increase calcium levels in the blood.
Bifidobacterium bifidum. Found in the large intestine, bifidum helps modulate the immune system and decreases inflammation throughout the body, including the musculoskeletal system. In addition, it helps fight candida and other yeast overgrowth.
Bifidobacterium breve. Good news for athletes — this probiotic has been shown in clinical settings to reduce inflammation and improve inflammatory response to exercise, both during and after training. As a result, it may play a critical role in recuperation from intense workouts and help improve recovery after training.
Bifidobacterium longum. This strain of Bifido helps influence fermentation of amino acids and carbs in the gut, which helps with muscle maintenance and energy levels. Fermentation breaks down the macronutrients so they can be absorbed and assimilated more easily.
Bacillus coagulans. This is actually a probiotic spore (lactic-acid-forming bacterium) that is designed to pass through the harsh acidity of the stomach and then become active when it enters the large intestine. It is known to improve immune health and enhance response to respiratory tract infections. Better yet for athletes, one such Bacillus coagulans spore (BC30) was shown in clinical research to speed recovery and reduce muscle damage when supplemented with protein.
Bacillus subtilis. This probiotic assists with digestion by producing enzymes, thereby helping with the digestion of proteins, lipids, amylose, pectin and cellulose. While supporting immune health, it also stimulates the growth of Lactobacilli in the gut. One particular Bacillus subtilis spore (DE111) was shown in separate clinical studies to optimize complex carb and fat digestion, improve body composition and promote regularity among long-distance runners

Artificial sweeteners have toxic effects on gut microbes

FDA-approved artificial sweeteners and sport supplements were found to be toxic to digestive gut microbes, according to a new paper published in Molecules by researchers at Ben-Gurion University of the Negev (BGU) in Israel and Nanyang Technological University in Singapore.
The collaborative study indicated relative toxicity of six artificial sweeteners (aspartame, sucralose, saccharine, neotame, advantame, and acesulfame potassium-k) and 10 sport supplements containing these artificial sweeteners. The bacteria found in the digestive system became toxic when exposed to concentrations of only one mg./ml. of the artificial sweeteners.
"We modified bioluminescent E. coli bacteria, which luminesce when they detect toxicants and act as a sensing model representative of the complex microbial system," says Prof. Ariel Kushmaro, John A. Ungar Chair in Biotechnology in the Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, and member of the Ilse Katz Institute for Nanoscale Science and Technology and the National Institute for Biotechnology in the Negev. "This is further evidence that consumption of artificial sweeteners adversely affects gut microbial activity which can cause a wide range of health issues."
Artificial sweeteners are used in countless food products and soft drinks with reduced sugar content. Many people consume this added ingredient without their knowledge. Moreover, artificial sweeteners have been identified as emerging environmental pollutants, and can be found in drinking and surface water, and groundwater aquifers.
"The results of this study might help in understanding the relative toxicity of artificial sweeteners and the potential of negative effects on the gut microbial community as well as the environment.
Furthermore, the tested bioluminescent bacterial panel can potentially be used for detecting artificial sweeteners in the environment," says Prof. Kushmaro.
Story Source:
Materials provided by American Associates, Ben-Gurion University of the NegevNote: Content may be edited for style and length.

Journal Reference:
  1. Dorin Harpaz, Loo Yeo, Francesca Cecchini, Trish Koon, Ariel Kushmaro, Alfred Tok, Robert Marks, Evgeni Eltzov. Measuring Artificial Sweeteners Toxicity Using a Bioluminescent Bacterial PanelMolecules, 2018; 23 (10): 2454 DOI: 10.3390/molecules23102454

Researchers have discovered how to slow aging

Previous research published earlier this year in Nature Medicine involving University of Minnesota Medical School faculty Paul D. Robbins and Laura J. Niedernhofer and Mayo Clinic investigators James L. Kirkland and Tamara Tchkonia, showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life. They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan.
As people age, they accumulate damaged cells. When the cells get to a certain level of damage they go through an aging process of their own, called cellular senescence. The cells also release inflammatory factors that tell the immune system to clear those damaged cells. A younger person's immune system is healthy and is able to clear the damaged cells. But as people age, they aren't cleared as effectively. Thus they begin to accumulate, cause low level inflammation and release enzymes that can degrade the tissue.
Robbins and fellow researchers found a natural product, called Fisetin, reduces the level of these damaged cells in the body. They found this by treating mice towards the end of life with this compound and see improvement in health and lifespan. The paper, "Fisetin is a senotherapeutic that extends health and lifespan," was recently published in EBioMedicine.
"These results suggest that we can extend the period of health, termed healthspan, even towards the end of life," said Robbins. "But there are still many questions to address, including the right dosage, for example."
One question they can now answer, however, is why haven't they done this before? There were always key limitations when it came to figuring out how a drug will act on different tissues, different cells in an aging body. Researchers didn't have a way to identify if a treatment was actually attacking the particular cells that are senescent, until now.
Under the guidance of Edgar Arriaga, a professor in the Department of Chemistry in the College of Science and Engineering at the University of Minnesota, the team used mass cytometry, or CyTOF, technology and applied it for the first time in aging research, which is unique to the University of Minnesota.
"In addition to showing that the drug works, this is the first demonstration that shows the effects of the drug on specific subsets of these damaged cells within a given tissue." Robbins said.
Story Source:
Materials provided by University of Minnesota Medical SchoolNote: Content may be edited for style and length.

Journal Reference:
  1. Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I. Melos, Tamar Pirtskhalava, Christina L. Inman, Collin McGuckian, Erin A. Wade, Jonathon I. Kato, Diego Grassi, Mark Wentworth, Christin E. Burd, Edgar A. Arriaga, Warren L. Ladiges, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Laura J. Niedernhofer. Fisetin is a senotherapeutic that extends health and lifespanEBioMedicine, 2018; DOI: 10.1016/j.ebiom.2018.09.015

Monday, September 24, 2018

Latest research hints at predicting autism risk for pregnant mothers

Researchers at Rensselaer Polytechnic Institute -- led by Juergen Hahn, professor and head of biomedical engineering -- are continuing to make remarkable progress with their research focused on autism spectrum disorder (ASD). A recent paper authored by Hahn and Jill James from the University of Arkansas for Medical Sciences (UAMS) in the journal Research in Autism Spectrum Disorders discusses their work on predicting with approximately 90 percent accuracy whether a pregnant mother has a 1.7 percent or a tenfold increased risk of having a child diagnosed with ASD.
Currently there is no test for pregnant mothers that can predict the probability of having a child that will be diagnosed with ASD. Recent estimates indicate that if a mother has previously had a child with ASD, the risk of having a second child with ASD is approximately 18.7 percent, whereas the risk of ASD in the general population is approximately 1.7 percent.
"However," said Hahn, a member of the Rensselaer Center for Biotechnology and Interdisciplinary Studies, "it would be highly desirable if a prediction based upon physiological measurements could be made to determine which risk group a prospective mother falls into."
Hahn's work in developing a physiological test to predict autism risk is part larger emphasis on Alzheimer's and neurodegenerative diseases at the Center for Biotechnology and Interdisciplinary Studies, and an example of how the interdisciplinary life science and engineering interface at Rensselaer offers new perspectives and solutions for improving human health.
In this study, metabolites of the folate-dependent transmethylation and transsulfuration biochemical pathways of pregnant mothers were measured to determine whether or not the risk of having a child with autism could be predicted by her metabolic profile. Pregnant mothers who have had a child with autism before were separated into two groups based on the diagnosis of their child whether the child had autism or not. Then these mothers were compared to a group of control mothers who have not had a child with autism before.
The researchers concluded that while it is not possible to determine during a pregnancy if a child will be diagnosed with ASD by age 3, they did find that differences in the plasma metabolites are indicative of the relative risk (18.7 percent vs 1.7 percent) for having a child with ASD.
"These are exciting results as they hint at differences in some metabolic processes that potentially play a role in increasing the risk of having a child with ASD," said Hahn.
In addition to the lead authors, Juergen Hahn of Rensselaer and Jill James of UAMS, this work included collaborators from Rensselaer, the University of Arkansas for Medical Sciences, and the MIND Institute at UC Davis.
This new research follows an earlier study published in 2017, which developed an algorithm based on levels of metabolites found in a blood sample that can accurately predict whether a child is on the autism spectrum. A follow-up study this spring was also highly promising in assessing whether a child is on the autism spectrum. These results have the potential for earlier diagnosis for ASD, and efforts are underway to develop a commercially available test based upon these findings.
Story Source:
Materials provided by Rensselaer Polytechnic InstituteNote: Content may be edited for style and length.

Journal Reference:
  1. Kathryn Hollowood, Stepan Melnyk, Oleksandra Pavliv, Teresa Evans, Ashley Sides, Rebecca J. Schmidt, Irva Hertz-Picciotto, William Elms, Elizabeth Guerrero, Uwe Kruger, Juergen Hahn, S. Jill James. Maternal metabolic profile predicts high or low risk of an autism pregnancy outcomeResearch in Autism Spectrum Disorders, 2018; 56: 72 DOI: 10.1016/j.rasd.2018.09.003

A fracture anywhere reduces bone density everywhere

Breaking a bone causes bone density losses throughout the body, not just close to the site of the fracture, and primarily around the time of the fracture, two new studies from UC Davis Health show.
The studies are among the first to associate fractures with systemic bone loss. They also begin the path to finding treatments that preserve long-term skeletal health and reduce susceptibility to additional fractures and, potentially, osteoporosis, which is diagnosed when bone-density losses are severe.
Both investigations were led by Blaine Christiansen, whose research focuses on identifying changes in musculoskeletal tissue due to injury, aging or disease.
"We know one fracture seems to lead to others, but we haven't known why," said Christiansen, associate professor of orthopaedic surgery at UC Davis. "Our work is the first step on the path to identifying the cellular mechanisms of systemic bone loss."
The first study, published in Osteoporosis International, was based on about 4,000 participants in the Study of Osteoporotic Fractures, an observational study of older women that included hip bone mineral density (BMD) measures and fracture history gathered regularly over 20 years.
Outcomes showed that hip BMD decreased over time for all women in the study, but was greatest for those who had fractured a bone ? even if the fracture was not near the hip. BMD reductions averaged between .89 and .77 percent per year for those with fractures, and .66 percent per year for those with no fractures. Those losses were greatest within the first two years of a break.
Published in the Journal of Bone and Mineral Research, the second study was conducted using mice with femur fractures and BMD tests in various bones. Once again, bone loss occurred throughout the body, most notably in the spine, and was greatest within the first two weeks of fracture. It also was accompanied by higher levels of inflammatory markers in the blood.
Outcomes of the second study showed interesting age-related recovery differences as well. Younger mice eventually recovered their pre-fracture BMD levels, while older mice did not.
Christiansen next hopes to further characterize the post-fracture inflammatory factors that may contribute to bone loss following fracture.
"It's possible that these factors are key to initiating BMD loss once a bone is broken," Christiansen said. "Ultimately, we hope to develop therapeutic strategies that interrupt those processes and prevent bone loss."
Story Source:
Materials provided by University of California - Davis Health SystemNote: Content may be edited for style and length.

Journal Reference:
  1. B. A. Christiansen, S. L. Harrison, H. A. Fink, N. E. Lane. Incident fracture is associated with a period of accelerated loss of hip BMD: the Study of Osteoporotic FracturesOsteoporosis International, 2018; 29 (10): 2201 DOI: 10.1007/s00198-018-4606-6

Weight loss can be boosted fivefold thanks to novel mental imagery technique

Overweight people who used a new motivational intervention called Functional Imagery Training (FIT) lost an average of five times more weight than those using talking therapy alone, shows new research published today by the University of Plymouth and Queensland University.
In addition, users of FIT lost 4.3cm more around their waist circumference in six months -- and continued to lose weight after the intervention had finished.
Led by Dr Linda Solbrig from the School of Psychology, the research involved 141 participants, who were allocated either to FIT or Motivational Interviewing (MI) -- a technique that sees a counsellor support someone to develop, highlight and verbalise their need or motivation for change, and their reasons for wanting to change.
FIT goes one step further than MI, as it makes use of multisensory imagery to explore these changes by teaching clients how to elicit and practice motivational imagery themselves. Everyday behaviours and optional app support are used to cue imagery practice until it becomes a cognitive habit.
Maximum contact time was four hours of individual consultation, and neither group received any additional dietary advice or information.
Dr Solbrig, who completed the work as part of a PhD funded by The National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) South West Peninsula, said: "It's fantastic that people lost significantly more weight on this intervention, as, unlike most studies, it provided no diet/physical activity advice or education. People were completely free in their choices and supported in what they wanted to do, not what a regimen prescribed."
The study showed how after six months people who used the FIT intervention lost an average of 4.11kg, compared with an average of 0.74kg among the MI group.
After 12 months -- six months after the intervention had finished -- the FIT group continued to lose weight, with an average of 6.44kg lost compared with 0.67kg in the MI group.
Dr Solbrig continued: "Most people agree that in order to lose weight, you need to eat less and exercise more, but in many cases, people simply aren't motivated enough to heed this advice -- however much they might agree with it. So FIT comes in with the key aim of encouraging someone to come up with their own imagery of what change might look and feel like to them, how it might be achieved and kept up, even when challenges arise.
"We started with taking people through an exercise about a lemon. We asked them to imagine seeing it, touching it, juicing it, drinking the juice and juice accidently squirting in their eye, to emphasise how emotional and tight to our physical sensations imagery is. From there we are able to encourage them to fully imagine and embrace their own goals. Not just 'imagine how good it would be to lose weight' but, for example, 'what would losing weight enable you to do that you can't do now? What would that look / sound / smell like?', and encourage them to use all of their senses.
"As well as being delighted by the success of the study in the short term, there are very few studies that document weight loss past the end of treatment, so to see that people continued to lose weight despite not having any support shows the sustainability and effectiveness of this intervention."
Trisha Bradbury was one of the participants allocated to the FIT study, and she explains: "I lost my mum at 60, and being 59 myself with a variety of health problems, my motivation was to be there for my daughter. I kept thinking about wearing the dress I'd bought for my daughter's graduation, and on days I really didn't feel like exercising, kept picturing how I'd feel.
"I've gone from 14 stone to 12 stone 2 and have managed to lower the dosage I need for my blood pressure tablets. I'd still like to lose a touch more, but I'm so delighted with the mind-set shift."
Professor Jackie Andrade, Professor in Psychology at the University of Plymouth, is one of the co-creators of FIT, and she explains: "FIT is based on two decades of research showing that mental imagery is more strongly emotionally charged than other types of thought. It uses imagery to strengthen people's motivation and confidence to achieve their goals, and teaches people how to do this for themselves, so they can stay motivated even when faced with challenges. We were very excited to see that our intervention achieved exactly what we had hoped for and that it helped our participants achieve their goals and most importantly to maintain them."
Story Source:
Materials provided by University of PlymouthNote: Content may be edited for style and length.

Journal Reference:
  1. Linda Solbrig, Ben Whalley, David J. Kavanagh, Jon May, Tracey Parkin, Ray Jones, Jackie Andrade. Functional imagery training versus motivational interviewing for weight loss: a randomised controlled trial of brief individual interventions for overweight and obesityInternational Journal of Obesity, 2018; DOI: 10.1038/s41366-018-0122-1