Thursday, October 18, 2018

Conceptual framework to study role of exercise in multiple sclerosis

Researchers have proposed a conceptual framework for examining the relationship between exercise and adaptive neuroplasticity in the population with multiple sclerosis (MS). The article, " Integrative CNS Plasticity with Exercise in MS: The PRIMERS (PRocessing, Integration of Multisensory Exercise-Related Stimuli) Conceptual Framework," was published in Neurorehabilitation and Neural Repair 2018 Sep 12.
Researchers are increasingly exploring the effects of exercise in various clinical populations, but little attention is being focused on the neural mechanisms that underlie positive changes in mobility and cognition. Using this conceptual framework will enable scientists to systematically examine the effects of exercise on brain connectivity, brain structure, and molecular/cellular mechanisms in the population with MS, and develop new strategies for rehabilitative care.
"Many individuals with MS develop disabling deficits in mobility and cognition," said John DeLuca, PhD, senior VP of Research and Training at Kessler Foundation, and a co-author of the article. "Exercise is a low-cost, non-invasive modality that relieves both types of symptoms," noted Dr. DeLuca, "so we are very interested in learning more about how activity results in these improvements. Rethinking how we view exercise in our plans for the long-term management of people with MS and other neurological conditions is our first step. We anticipate that use of the PRIMERS framework will accelerate advances in treatment by integrating the contributions from neuroscience, neurophysiology, and neurorehabilitation," Dr. DeLuca concluded.
Story Source:
Materials provided by Kessler FoundationNote: Content may be edited for style and length.

Journal Reference:
  1. Brian M. Sandroff, Robert W. Motl, William R. Reed, Aron K. Barbey, Ralph H. B. Benedict, John DeLuca. Integrative CNS Plasticity With Exercise in MS: The PRIMERS (PRocessing, Integration of Multisensory Exercise-Related Stimuli) Conceptual FrameworkNeurorehabilitation and Neural Repair, 2018; 32 (10): 847 DOI: 10.1177/1545968318798938

Omega 3 fatty acids found in seafood linked to healthy aging

Higher blood levels of omega 3 fatty acids found in seafood are associated with a higher likelihood of healthy ageing among older adults, finds a US study published by The BMJ today.
With populations across the world living longer, there is a growing focus on healthy ageing -- a meaningful lifespan without major chronic diseases and with good physical and mental function.
Previous studies suggest that omega 3 polyunsaturated fatty acids (n-3 PUFAs) derived from seafood and plants may have beneficial effects on the body that could promote healthy ageing, but results are inconsistent.
So a team of US researchers, led by Heidi Lai at the Friedman School of Nutrition Science and Policy at Tufts University in Boston, set out to investigate the association between circulating blood levels of n-3 PUFAs and healthy ageing among older adults.
The study involved 2,622 adults who were taking part in the US Cardiovascular Health study from 1992 to 2015. Average age of participants at the start of the study (baseline) was 74 years, 63% were women and 11% were from non-white groups.
Blood levels of n3-PUFAs were measured at baseline, 6, and 13 years. These included eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and alpha linolenic acid (ALA). The main dietary sources of EPA, DHA and DPA come from seafood, while ALA is found mainly in plants (nuts, seeds, and leafy green vegetables).
Based on these measurements, participants were split into five groups (quintiles) of circulating blood n-3 PUFA levels, from lowest to highest.
Through review of medical records and diagnostic tests, the researchers found that 89% of the participants experienced unhealthy ageing over the study period, while 11% experienced healthy ageing -- defined as survival free of major chronic diseases and without mental or physical dysfunction.
After taking account of a range of other social, economic, and lifestyle factors, the researchers found that levels of seafood-derived EPA in the highest quintile were associated with a 24% lower risk of unhealthy ageing than levels in the lowest quintile.
For DPA levels, the top three quintiles were associated with an 18-21% reduction in the risk of unhealthy ageing. However, seafood-derived DHA and plant-derived ALA were not associated with healthy ageing.
A possible explanation for this effect is that n-3 PUFAs help to regulate blood pressure, heart rate and inflammation, explain the authors.
They point out that this was an observational study, so no firm conclusions can be drawn about cause and effect, and they cannot rule out the possibility that some of the observed risk may be due to other unmeasured factors.
The study had a long (up to 22 years) follow-up period, and results remained largely unchanged after further analyses.
As such, they say that, among older adults, higher levels of circulating n-3 PUFAs from seafood were associated with a lower risk of unhealthy ageing.
"These findings encourage the need for further investigations into plausible biological mechanisms and interventions related to n3-PUFAs for maintenance of healthy ageing, and support guidelines for increased dietary consumption of fish among older adults," they conclude.
In a linked editorial, Professor Yeyi Zhu at Kaiser Permanente Northern California Division of Research and the University of California and colleagues say this study makes a valuable contribution to our understanding of the effect n3-PUFAs might have on ageing. But they caution against using these findings to inform public health policy or nutritional guidelines.
We live in challenging times, when lifespans are increasing but healthy lifespans are not, they write. "Following the World Health Organization's policy framework for healthy ageing, any evidence-based clues to improve health in later life are welcome but additional efforts to accelerate this area of research are essential," they conclude.
Story Source:
Materials provided by BMJNote: Content may be edited for style and length.

Journal Reference:
  1. Heidi TM Lai, Marcia C de Oliveira Otto, Rozenn N Lemaitre, Barbara McKnight, Xiaoling Song, Irena B King, Paulo HM Chaves, Michelle C Odden, Anne B Newman, David S Siscovick, Dariush Mozaffarian. Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort studyBMJ, 2018; k4067 DOI: 10.1136/bmj.k4067

Children with autism, developmental delays nearly 50 percent more likely to be overweight, obese

A new study by researchers at Children's Hospital of Philadelphia (CHOP), the University of Pennsylvania and six other centers reveals that children with developmental delays, including autism spectrum disorder (ASD), are up to 50 percent more likely to be overweight or obese compared with the general population.
The findings were published online by The Journal of Pediatrics.
This is the first large study to demonstrate that young children with ASD or developmental delays are at an equally high risk of developing obesity. Among children with ASD, those with a higher degree of impairment and more severe symptoms were found to be at even greater risk of developing obesity by age five.
The study included nearly 2,500 children between the ages of two and five years old. This age group is especially relevant, since it is an important window for early obesity prevention.
The research was conducted as part of the Study to Explore Early Development (SEED). The multisite study analyzed 668 children with ASD, 914 children with developmental delays or disorders and 884 children from the general population who served as controls. Children's heights and weights were measured during clinical visits, and ASD severity was measured using the Ohio State University Global Severity Scale for Autism.
The study showed that children with ASD were 1.57 times more likely to be overweight or obese than the general population. Children with developmental delays were 1.38 times more likely to be overweight or obese. The risk for obesity was even more pronounced in children with severe ASD symptoms, as they were 1.7 times more likely to be classified as overweight or obese than children with mild ASD symptoms.
"These findings make it clear that monitoring these children for excess weight gain at an early age is critical, and that prevention efforts should be expanded to include not just children with ASD, but those with other developmental diagnoses, as well," said Susan E. Levy, MD, MPH, the study's lead author and medical director of the Center for Autism Research at CHOP.
Although increased obesity in children with ASD has been reported in other studies, this study is the first to examine if children with other developmental disabilities are also at increased risk for developing obesity. Also, the researchers examined connections between excess weight gain and the presence of other medical, behavioral, developmental, or psychiatric conditions.
"We need more research to understand why these children are more likely to develop obesity, and which children are at the highest risk," said Levy. Other medical conditions are especially common among children with ASD, and the authors note that these may play a role in excess weight gain. Possible factors include endocrine disorders, genetic disorders, gastrointestinal symptoms, medication-associated side effects, sleep disturbances, or rigid food choices, among others.
The research findings may shed light into possible mechanisms underlying the increased obesity risk in children with ASD, which may offer targets for early intervention. The authors suggest that clinicians monitor children who receive a diagnosis of ASD or developmental delays/disorders for signs of excess weight gain, and that they provide specific guidance for their parents in an effort to prevent obesity. Parents should discuss with their medical caregiver any concerns they have about their child who may be showing signs of obesity.
Story Source:
Materials provided by Children's Hospital of PhiladelphiaNote: Content may be edited for style and length.

Journal Reference:
  1. Susan E. Levy, Jennifer A. Pinto-Martin, Chyrise B. Bradley, Jesse Chittams, Susan L. Johnson, Juhi Pandey, Alison Pomykacz, AnnJosette Ramirez, Ann Reynolds, Eric Rubenstein, Laura A. Schieve, Stuart K. Shapira, Aleda Thompson, Lisa Young, Tanja V.E. Kral. Relationship of Weight Outcomes, Co-Occurring Conditions, and Severity of Autism Spectrum Disorder in the Study to Explore Early DevelopmentThe Journal of Pediatrics, 2018; DOI: 10.1016/j.jpeds.2018.09.003

Tuesday, October 2, 2018

The Pros and Cons of Cardio

There’s something gratifying about a workout that makes your sweaty clothes stick to your skin and your hair a hopeless mess of frizz and flyaways. No doubt, a heart-pumping cardio session can eliminate fat, along with stress and frustration.
Done right, there are many benefits to performing aerobic exercise. However, we’ve all seen the cardio bunny at our gym. It’s the person who runs on the treadmill for hours on end or the person using the elliptical with minimal resistance, going as fast as he or she can. And how often do you see that person leaning on the rails of the StepMill?
Whether you prefer to perform cardio or would rather stick with the weights, it’s important to understand the pros and cons of aerobic exercise.

Pro: The Brain Benefit

Research suggests that aerobic exercise helps improve neuroplasticity and neurogenesis. Basically, cardio exercise improves how your existing brain cells function and helps create new ones.

Pro: Improved Sleep

As little as 10 minutes of aerobic exercise, such as walking or cycling, can improve the quality of your nighttime sleep. People who exercise regularly may reduce their risk of sleep apnea, restless leg syndrome and other sleep disorders. If you still struggle to fall (and stay) asleep, consider a melatonin supplement.

Pro: Reduced Risk of Heart Disease

When you work out aerobically, you put stress on your cardiovascular system. Over time, this system adapts and becomes stronger. The result? Your blood pressure may lower and HDL levels (the good cholesterol) may increase. This increased efficiency means less work for your body, heart and blood vessels — reducing your risk of diabetes, coronary artery disease, heart attack and more.

Con: Overtraining

Logging countless hours of cardio can leave you physically and mentally exhausted. If you’re a marathon runner, keep on running, but use caution when following an extensive cardio cross-training program. Whether you’re training for an event or if your goal is simply to improve your fitness, the body needs time to rest and repair. This will reduce your risk of overuse injuries — your body’s way of telling you to slow down.

Con: Muscle Loss

When the body is in a caloric-deficit state, it turns to muscle as a fuel source. Without adequate fuel, you risk losing your hard-earned muscle mass. Including cardio in your routine can actually improve your recovery from other forms of exercise, such as lifting weights, by stimulating blood flow to your working muscles.

Con: Fat Retention

If you want to lose weight, you amp up your cardio routine, right? Not always. Your body adapts to the stress you are placing on it. Improvement will require you to overload the muscles and your aerobic system. If cycling or walking or swimming are your go-to exercises, then you are forced to do more and more in order to see continual progress. Increased cardio can lead to decreased muscle mass, resulting in a lower, less efficient metabolic rate. Keep in mind that strength training helps your body maintain metabolically active muscle mass. It is the perfect complement to cardiovascular exercise.
We all aim to achieve that euphoric, post-cardio high that inspires us to finally clean the house or go to the grocery store and stock up on fruit, veggies and everything else that falls into the “healthy” perimeter of the store. However, it’s important to understand the difference between “too much” and “not enough.” It is recommended that you exercise aerobically 30 to 40 minutes per workout, three or four times per week. You can achieve this in increments throughout the day. Aim for an intensity level that’s 55 to 85 percent of your maximal heart rate.
By finding the balance that works for you, based on your goals and current fitness level, you will achieve that sweat-inducing sweet spot while experiencing the benefits of a heart-healthy workout.

Macros: What Are They and Why Do I Need Them?

Have you asked yourself, “Why are people so obsessed with these things?” Perhaps you’ve let out a sigh and dismissed them as “fads” in the fitness industry. Those leopard print leggings will go out of style before anyone can finish sipping their skinny tea, right? While that’s quite possible, it’s not necessarily true for macros (or for aerial yoga, for that matter). Talk of macros is spreading like wildfire on the internet and social media, and rightfully so. Before you get caught up counting them, it’s important to know what they are and why you need them.
“Macros” are short for macronutrients. They consist of three food categories: carbohydrates, fats and proteins. Each system in your body depends on the availability of these three macronutrients. Macronutrients affect things like body composition, appetite, satiety, likelihood of disease and its progression, perceived energy levels and your ability to recover from exercise. We’re going to talk more about the role of each, along with recommended food choices.

Carbohydrates

Carbohydrates are the brain and central nervous system’s primary choice of fuel. When carb intake is low, brain fog and a decrease in athletic performance may result. The Dietary Guidelines Advisory Committee suggests a minimum intake of 130 grams per day to meet basic energy needs to sustain bodily systems. However, your total carb intake will vary based on activity levels, goals, genetics and body size. In general, aim for a carb intake of 45 to 65 percent of total calories. Slow-digesting, minimally processed foods with sufficient fiber are the best choices.
• Oats
• Vegetables
• Fruits
• Barley
• Flaxseed

Fats

There are many roles fat plays throughout your body. It is the most energy-dense nutrient, and it helps manufacture and balance hormones. It also helps transport fat-soluble vitamins. Overconsumption of fat may lead to an increased risk of heart disease. This effect seems to occur when saturated fat intake is high and the diet is also high in sugar and processed carbohydrates. Excess body fat also can result from this scenario. Avoid vegetable oils rich in omega-6 such as corn oil, safflower oil, sunflower oil and cottonseed oil. Fats should make up 20 to 35 percent of your total calories.
• Walnuts
• Avocado
• Salmon
• Olive oil

Protein

Carbohydrates and fats are managed efficiently by the body. However, it’s difficult to maintain adequate protein levels without a proper diet. If your diet lacks amino acids (building blocks of protein) that your body can’t make on its own, your muscular structure, hormone levels and enzyme levels will suffer. Protein quality will vary based on a food’s level of amino acids. Animal proteins typically rank higher, while plant proteins (although they do contain all the essential amino acids) rank lower. Most healthy adults require 0.8 grams of protein per kilogram of bodyweight. Some experts suggest aiming for 1 gram of protein per pound of bodyweight, since higher amounts of protein are associated with improved immune healthy, metabolism and weight management.
• Eggs
• Cottage cheese
• Lentils
• Whey protein 
• Chicken

Probiotics For Athletes

Probiotics are all the rage today — whether they be in the form of foods naturally rich in this beneficial bacteria (such as yogurt) or specific supplements standardized to specific strengths. And with good reason, your body is home to more than 100 trillionmicroorganisms. This means that the bacteria in your body outnumber all your cells by 10 to 1!
The vast majority of these bacteria reside in your gut. About 70 percent of them represent healthy (“good”) bacteria, while the remaining 30 percent are “bad” and are detrimental to your system. The flora in your gut perform a variety of functions that are essential to your health. In fact, it’s estimated that 70 percent of your immune cells are located in your intestinal tract, making the health of your digestive system essential to overall bodily health.
Research shows that the health of the digestive system dramatically affects digestion and absorption of nutrients, immune function, skin health, cognitive ability, metabolism and even muscle mass, body composition and endurance. Probiotics help regulate the balance of microbial cells — bacteria and yeast — that exist there. An imbalance in the gut microbia can lead to diarrhea, constipation, inflammatory bowel and other gut ailments, plus numerous health ailments stemming from a compromised immune system.
Gut microbial balance is adversely affected by poor diet, infections, antibiotic treatments and other external factors. To restore this balance, ingesting live probiotic bacteria is vital. Probiotics are measured in colony-forming units (CFU), which determine how much of the bacteria can divide into colonies in your system. Typically, the higher the CFU, the more beneficial the food or supplement (to a point, which will be explained later).
Foods naturally rich in probiotic “bugs” include yogurt, kefir, raw cheese, sourdough bread and various fermented foods such as apple cider vinegar, kombucha and kvass. However, because you’d have to consume significant amounts of these foods on a daily basis to achieve adequate quantities of beneficial bacteria, supplementation via probiotic capsules, tablets or gummies is generally required for improved health.

PERFORMANCE, IMMUNITY AND BODY COMPOSITION

Athletes have extremely high nutrient requirements because of the stress of high-intensity training, competition and an overall active lifestyle. The preponderance of protein intake and high amount of carbohydrates necessary to fuel activity puts added strain on the digestive system, plus can upset microorganism balance by reducing probiotic counts. This is aggravated by sheer caloric intake, which often takes the form of fast food or similar, less-than-optimal choices. Over time, this becomes chronic and food intake doesn’t equate to nutrient absorption, which may lead to a catabolic effect on muscle tissue and can adversely affect overall performance.
Protein intake is one issue of vital importance to athletes because of its role in recovery and muscle building. Because your body can only digest about 25 grams of protein at a time, the more you are able to absorb amino acids from what you consume, the greater your anabolic growth potential. Emerging research demonstrates that probiotics play a key role in the muscle growth process and improved recovery by increasing uptake of amino acids in the small intestine. For example, the BC30 form of the probiotic spore Bacillus coagulanswas shown in research to increase protein uptake, leading to reduced muscle damage, decreased muscle soreness and improved recovery among athletes.
In addition, the athletic and fitness activities we pursue to improve our bodies and competitive performance also can have an adverse effect on immune response. For instance, an athlete can be more prone to bacterial and viral infections for up to 72 hours after training. This happens because the body is subjected to acute changes in the secretion of antibodies during intense activity.
Probiotics can help because they adhere to the gut lining and create a barrier of sorts that helps prevent the adhesion of pathogens that will make you sick. They also bolster that critical 70 percent of the immune system found in your digestive tract, which means enhanced recovery and recuperation from intense activity.
What’s worse, the sport or activity you choose can exacerbate problems in your gut. For instance, it is estimated that 30 to 60 percent of long-distance runners are impacted by gastrointestinal discomfort. Because blood flow is directed to muscles during extended running bouts, reduced blood flow in the digestive tract leads to malabsorption of food. It can be so bad that many runners are afflicted with acute diarrhea.
For all these reasons, use of daily probiotics (whether from food or supplement sources) is a proven way to improve your fitness and athletic performance. In addition, improving and maintaining immune system health is critical for long-term athletic success by maximizing recovery and minimizing lost training days because of illness or malaise.
As an added bonus, probiotic supplementation has also been shown to have a beneficial effect on body composition. In one clinical study, female athletes who consumed a specific form of the highly beneficial Bacillus subtilis probiotic (DE111) over 10 weeks postworkout with a protein drink significantly decreased body-fat percentage. In addition, they also performed better in the deadlift exercise during weight training.

WHICH ONES AND HOW MUCH?

So the evidence is clear — probiotics are key to improved athletic performance, recovery and overall health. To take full advantage of these beneficial bacteria, finding the right probiotics for your needs takes a little research. It’s not necessarily a one-size-fits-all supplement.
From the CFU standpoint, more is not always better. While supplements with 10 or 15 billion CFU are generally more powerful than ones with 5 billion, ingesting too much in supplement form can actually cause stomach upset — the exact opposite of the intended result. Experts say 50 billion is probably the maximum daily amount needed, although this might be excessive for many people.
As to which probiotics you should use, this can depend on the specific effect you’re seeking. While all of them enhance digestion and improve immune response, some are more effective than others. And several have very specific researched benefits for athletes. What follows are some popular probiotic strains and the specific sports and fitness benefits they can impart. Fortunately, multiple strains are often packaged together for greater benefit. Just be sure the benefits you’re seeking can be matched to the probiotics (and adequate CFU count) in the products you purchase.
TOP PROBIOTICS FOR ATHLETES
Lactobacillus acidophilus. This is the most researched and proven probiotic, having been the subject of thousands of studies. It provides many benefits, including digestive health and pH balance, improvements in blood pressure and production of enzymes that help in milk digestion. It is also critical in nutrient absorption, immune response and the ability to fight bacterial, fungal and viral infections.
Lactobacillus rhamnosus. This probiotic helps to inhibit bacterial infections. One patented strain of rhamnosus known as Lactobacillus gg is best known for stimulating the immune system, fighting allergies, reducing systemic inflammation and improving blood sugar control.
Lactobacillus plantarum. This bug has been shown to increase iron absorption and improve iron levels. It also has a powerful effect on the immune system and can help reduce the risk of acquiring the common cold. Better yet, research suggests it may help you decrease bodyweight and build muscle mass in as little as six weeks of consistent use. Finally, this bug was shown in a clinical study to increase physical endurance, especially when exercising in heat.
Lactobacillus helveticus. Because it can improve sleep quality and duration, this probiotic is beneficial for recovery for hard training athletes. It is also shown in studies to reduce blood pressure and increase calcium levels in the blood.
Bifidobacterium bifidum. Found in the large intestine, bifidum helps modulate the immune system and decreases inflammation throughout the body, including the musculoskeletal system. In addition, it helps fight candida and other yeast overgrowth.
Bifidobacterium breve. Good news for athletes — this probiotic has been shown in clinical settings to reduce inflammation and improve inflammatory response to exercise, both during and after training. As a result, it may play a critical role in recuperation from intense workouts and help improve recovery after training.
Bifidobacterium longum. This strain of Bifido helps influence fermentation of amino acids and carbs in the gut, which helps with muscle maintenance and energy levels. Fermentation breaks down the macronutrients so they can be absorbed and assimilated more easily.
Bacillus coagulans. This is actually a probiotic spore (lactic-acid-forming bacterium) that is designed to pass through the harsh acidity of the stomach and then become active when it enters the large intestine. It is known to improve immune health and enhance response to respiratory tract infections. Better yet for athletes, one such Bacillus coagulans spore (BC30) was shown in clinical research to speed recovery and reduce muscle damage when supplemented with protein.
Bacillus subtilis. This probiotic assists with digestion by producing enzymes, thereby helping with the digestion of proteins, lipids, amylose, pectin and cellulose. While supporting immune health, it also stimulates the growth of Lactobacilli in the gut. One particular Bacillus subtilis spore (DE111) was shown in separate clinical studies to optimize complex carb and fat digestion, improve body composition and promote regularity among long-distance runners

Artificial sweeteners have toxic effects on gut microbes

FDA-approved artificial sweeteners and sport supplements were found to be toxic to digestive gut microbes, according to a new paper published in Molecules by researchers at Ben-Gurion University of the Negev (BGU) in Israel and Nanyang Technological University in Singapore.
The collaborative study indicated relative toxicity of six artificial sweeteners (aspartame, sucralose, saccharine, neotame, advantame, and acesulfame potassium-k) and 10 sport supplements containing these artificial sweeteners. The bacteria found in the digestive system became toxic when exposed to concentrations of only one mg./ml. of the artificial sweeteners.
"We modified bioluminescent E. coli bacteria, which luminesce when they detect toxicants and act as a sensing model representative of the complex microbial system," says Prof. Ariel Kushmaro, John A. Ungar Chair in Biotechnology in the Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, and member of the Ilse Katz Institute for Nanoscale Science and Technology and the National Institute for Biotechnology in the Negev. "This is further evidence that consumption of artificial sweeteners adversely affects gut microbial activity which can cause a wide range of health issues."
Artificial sweeteners are used in countless food products and soft drinks with reduced sugar content. Many people consume this added ingredient without their knowledge. Moreover, artificial sweeteners have been identified as emerging environmental pollutants, and can be found in drinking and surface water, and groundwater aquifers.
"The results of this study might help in understanding the relative toxicity of artificial sweeteners and the potential of negative effects on the gut microbial community as well as the environment.
Furthermore, the tested bioluminescent bacterial panel can potentially be used for detecting artificial sweeteners in the environment," says Prof. Kushmaro.
Story Source:
Materials provided by American Associates, Ben-Gurion University of the NegevNote: Content may be edited for style and length.

Journal Reference:
  1. Dorin Harpaz, Loo Yeo, Francesca Cecchini, Trish Koon, Ariel Kushmaro, Alfred Tok, Robert Marks, Evgeni Eltzov. Measuring Artificial Sweeteners Toxicity Using a Bioluminescent Bacterial PanelMolecules, 2018; 23 (10): 2454 DOI: 10.3390/molecules23102454

Researchers have discovered how to slow aging

Previous research published earlier this year in Nature Medicine involving University of Minnesota Medical School faculty Paul D. Robbins and Laura J. Niedernhofer and Mayo Clinic investigators James L. Kirkland and Tamara Tchkonia, showed it was possible to reduce the burden of damaged cells, termed senescent cells, and extend lifespan and improve health, even when treatment was initiated late in life. They now have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan.
As people age, they accumulate damaged cells. When the cells get to a certain level of damage they go through an aging process of their own, called cellular senescence. The cells also release inflammatory factors that tell the immune system to clear those damaged cells. A younger person's immune system is healthy and is able to clear the damaged cells. But as people age, they aren't cleared as effectively. Thus they begin to accumulate, cause low level inflammation and release enzymes that can degrade the tissue.
Robbins and fellow researchers found a natural product, called Fisetin, reduces the level of these damaged cells in the body. They found this by treating mice towards the end of life with this compound and see improvement in health and lifespan. The paper, "Fisetin is a senotherapeutic that extends health and lifespan," was recently published in EBioMedicine.
"These results suggest that we can extend the period of health, termed healthspan, even towards the end of life," said Robbins. "But there are still many questions to address, including the right dosage, for example."
One question they can now answer, however, is why haven't they done this before? There were always key limitations when it came to figuring out how a drug will act on different tissues, different cells in an aging body. Researchers didn't have a way to identify if a treatment was actually attacking the particular cells that are senescent, until now.
Under the guidance of Edgar Arriaga, a professor in the Department of Chemistry in the College of Science and Engineering at the University of Minnesota, the team used mass cytometry, or CyTOF, technology and applied it for the first time in aging research, which is unique to the University of Minnesota.
"In addition to showing that the drug works, this is the first demonstration that shows the effects of the drug on specific subsets of these damaged cells within a given tissue." Robbins said.
Story Source:
Materials provided by University of Minnesota Medical SchoolNote: Content may be edited for style and length.

Journal Reference:
  1. Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I. Melos, Tamar Pirtskhalava, Christina L. Inman, Collin McGuckian, Erin A. Wade, Jonathon I. Kato, Diego Grassi, Mark Wentworth, Christin E. Burd, Edgar A. Arriaga, Warren L. Ladiges, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Laura J. Niedernhofer. Fisetin is a senotherapeutic that extends health and lifespanEBioMedicine, 2018; DOI: 10.1016/j.ebiom.2018.09.015