Sunday, November 18, 2018

Dietary fat is good? Dietary fat is bad? Coming to consensus

Which is better, a low-fat/high-carbohydrate diet or a high-fat/low-carbohydrate diet -- or is it the type of fat that matters? In a new paper featured on the cover of Science magazine's special issue on nutrition, researchers from Harvard T.H. Chan School of Public Health, Boston Children's Hospital, and colleagues with diverse expertise and perspectives on the issues laid out the case for each position and came to a consensus and a future research agenda.
The researchers agreed that no specific fat to carbohydrate ratio is best for everyone, and that an overall high-quality diet that is low in sugar and refined grains will help most people maintain a healthy weight and low chronic disease risk.
"This is a model for how we can transcend the diet wars," said lead author David Ludwig, professor in the Department of Nutrition at Harvard Chan School and a physician at Boston Children's Hospital. "Our goal was to assemble a team with different areas of expertise and contrasting views, and to identify areas of agreement without glossing over differences."
The review was published online November 15, 2018 in Science.
The authors laid out the evidence for three contrasting positions on dietary guidelines for fat and carbohydrate consumption:
  1. High consumption of fat causes obesity, diabetes, heart disease, and possibly cancer, therefore low-fat diets are optimal.
  2. Processed carbohydrates have negative effects on metabolism; lower-carbohydrate or ketogenic (very low-carbohydrate) diets with high fat content are better for health.
  3. The relative quantity of dietary fat and carbohydrate has little health significance -- what's important is the type of fat or carbohydrate source consumed.
They agreed that by focusing on diet quality -- replacing saturated or trans fats with unsaturated fats and replacing refined carbohydrates with whole grains and nonstarchy vegetables -- most people can maintain good health within a broad range of fat-to-carbohydrate ratios.
Within their areas of disagreement, the authors identified a list of questions that they said can form the basis of a new nutrition research agenda, including:
  1. Do diets with various carbohydrate-to-fat ratios affect body composition (ratio of fat to lean tissue) regardless of caloric intake?
  2. Do ketogenic diets provide metabolic benefits beyond those of moderate carbohydrate restriction, and especially for diabetes?
  3. What are the optimal amounts of specific types of fat (including saturated fat) in a very-low-carbohydrate diet?
Finding the answers to these questions, the researchers said, will ultimately lead to more effective nutrition recommendations.
Walter Willett, professor of epidemiology and nutrition at Harvard Chan School, is a co-author.
Ludwig was supported in part by a career award from the National Institute of Diabetes and Digestive and Kidney Diseases (K24DK082730). Ludwig, Willett, and Jeff Volek received royalties for books about obesity and nutrition that include recommendations on dietary fat. Volek is a founder, stockholder, and consultant for VirtaHealth Corp. and a member of the advisory boards for Atkins Nutritionals Inc., UCAN Co., and Axcess Global.
Story Source:
Materials provided by Harvard T.H. Chan School of Public HealthNote: Content may be edited for style and length.

Journal Reference:
  1. David S. Ludwig, Walter C. Willett, Jeff S. Volek, Marian L. Neuhouser. Dietary fat: From foe to friend? Science, 2018; 362 (6416): 764 DOI: 10.1126/science.aau2096

Friday, November 16, 2018

Low-carb diets cause people to burn more calories

Most people regain the weight they lose from dieting within one or two years, in part because the body adapts by slowing metabolism and burning fewer calories. A meticulous study led by Boston Children's Hospital, in partnership with Framingham State University, now finds that eating fewer carbohydrates increases the number of calories burned. The findings, published November 14 in the BMJ, suggest that low-carb diets can help people maintain weight loss, making obesity treatment more effective.
The study, known as the Framingham State Food Study, or (FS)2, tightly controlled what people ate by providing them with fully prepared food-service meals for a 20-week period. Researchers carefully tracked participants' weight and measured insulin secretion, metabolic hormones and total energy expenditure (calories burned).
"This is the largest and longest feeding study to test the 'Carbohydrate-Insulin Model,' which provides a new way to think about and treat obesity," says David Ludwig, MD, PhD, who is co-principal investigator with Cara Ebbeling, PhD. (Ludwig and Ebbeling are co-directors of the New Balance Foundation Obesity Prevention Center in Boston Children's Division of Endocrinology.) "According to this model, the processed carbohydrates that flooded our diets during the low-fat era have raised insulin levels, driving fat cells to store excessive calories. With fewer calories available to the rest of the body, hunger increases and metabolism slows -- a recipe for weight gain."
Comparing carb levels head to head
After careful telephone screening of 1,685 potential participants, Ebbeling, Ludwig and colleagues enrolled 234 overweight adults (age 18 to 65, body mass index of 25 or higher) to an initial weight-loss diet for about 10 weeks. Of these, 164 achieved the goal of losing 10 to 14 percent of body weight and went on to the study's maintenance phase.
These participants were then randomized to follow high-, moderate- or low-carbohydrate diets for an additional 20 weeks -- with carbs comprising 60, 40 and 20 percent of total calories, respectively. Carbs provided to all three groups were of high quality, conforming to guidelines for minimizing sugar and using whole rather than highly processed grains.
In all three groups, total calorie intake was adjusted to maintain weight loss, so participants' weight did not change notably. During this phase, the goal was to compare energy expenditure -- how the different groups burned calories at the same weight. Energy expenditure was measured by a gold-standard method using doubly labeled water.
Over the 20 weeks, total energy expenditure was significantly greater on the low-carbohydrate diet versus the high-carbohydrate diet. At the same average body weight, participants who consumed the low-carb diet burned about 250 kilocalories a day more than those on the high-carb diet.
"If this difference persists -- and we saw no drop-off during the 20 weeks of our study -- the effect would translate into about a 20-pound weight loss after three years, with no change in calorie intake," says Ebbeling.
In people with the highest insulin secretion at baseline, the difference in calorie expenditure between the low- and high-carb diets was even greater, about 400 kilocalories per day, consistent with what the Carbohydrate-Insulin Model would predict. Ghrelin, a hormone thought to reduce calorie burning, was significantly lower on the low- versus high-carb diet.
"Our observations challenge the belief that all calories are the same to the body," says Ebbeling. "Our study did not measure hunger and satiety, but other studies suggest that low-carb diets also decrease hunger, which could help with weight loss in the long term."
Ludwig and Ebbeling recently launched another clinical trial called FB4, in which 125 adults with obesity live in a residential center for 13 weeks. Participants are being randomized to one of three diets: very-low-carb, high carb/low sugar or high carb/high sugar diets, with their calorie intakes individually matched to their energy expenditure. Results are expected in 2021.
Story Source:
Materials provided by Boston Children's HospitalNote: Content may be edited for style and length.

Journal Reference:
  1. Cara B Ebbeling, Henry A Feldman, Gloria L Klein, Julia M W Wong, Lisa Bielak, Sarah K Steltz, Patricia K Luoto, Robert R Wolfe, William W Wong, David S Ludwig. Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trialBMJ, 2018; k4583 DOI: 10.1136/bmj.k4583

Can stimulating the brain treat chronic pain?

For the first time, researchers at the UNC School of Medicine showed they could target one brain region with a weak alternating current of electricity, enhance the naturally occurring brain rhythms of that region, and significantly decrease symptoms associated with chronic lower back pain.
The results, published in the Journal of Pain and presented at the Society for Neuroscience conference in San Diego this week, suggest that doctors could one day target parts of the brain with new noninvasive treatment strategies, such as transcranial alternating current stimulation, or tACS, which researchers used in this study to boost the naturally occurring brain waves they theorized were important for the treatment of chronic pain.
"We've published numerous brain stimulation papers over several years, and we always learn something important," said senior author Flavio Frohlich, PhD, director of the Carolina Center for Neurostimulation and associate professor of psychiatry. "But this is the first time we've studied chronic pain, and this is the only time all three elements of a study lined up perfectly. We successfully targeted a specific brain region, we enhanced or restored that region's activity, and we correlated that enhancement with a significant decrease in symptoms."
Co-first author Julianna Prim, a graduate student mentored by Karen McCulloch, PT, PhD, in the Department of Allied Health Sciences at the UNC School of Medicine, who works closely with Frohlich's lab, said, "If brain stimulation can help people with chronic pain, it would be a cheap, non-invasive therapy that could reduce the burden of opioids, which we all know can have severe side effects."
Chronic pain is the leading cause of disability in the world, but there is not consensus among scientists that brain activity plays a causal role in the condition. Frohlich says the pain research field has focused largely on peripheral causes of chronic pain. For example, if you have chronic lower back pain, then the cause and solution lie in the lower back and related parts of the nervous system in the spine. But some researchers and clinicians believe chronic pain runs deeper, that the condition can reorganize how cells in the nervous system communicate with each other, including networks of neurons in the brain. Over time, the theory goes, these networks get stuck in a kind of neural rut, essentially becoming a cause of chronic pain.
Previous studies showed that people with chronic pain experience abnormal neural oscillations, or brain waves. There are several kinds of brain waves related to different brain regions and various kinds of brain activities -- processing visual stimuli, memorization, creative thinking, etc. When we speak, think, eat, play sports, watch television, daydream, or sleep, our brain activity creates electrical patterns researchers can measure using electroencephalograms, or EEGs. These patterns fluctuate or oscillate, which is why they appear as waves that rise and fall on an EEG printout.
One type of brain activity is called alpha oscillations, which occur when we are not taking in stimuli. When we meditate in silence, daydream in the shower, or even when we're "in the zone" during athletic activity, alpha oscillations dominate the brain. Frohlich's lab wanted to know if these alpha oscillations were deficient in the somatosensory cortex, located in the middle portion of the brain and likely involved in chronic pain. If so, then could Frohlich's team enhance the alpha waves there? And if that were possible, would there be any pain relief?
Prim and colleagues recruited 20 patients with lower chronic back pain. Each of them reported back pain as "four" or greater for at least six months on the subjective scale of one to 10. Each participant volunteered for two 40-minute sessions that took place one to three weeks apart.
During all sessions, researchers attached an array of electrodes to the scalps of patients. During one session, researchers targeted the somatosensory cortex using tACS to enhance the naturally occurring alpha waves. During another session for all participants, researchers used a similar weak electrical current that was not targeted -- this was a sham or placebo stimulation session. During all sessions, participants felt tingling on their scalp. They could not tell the difference between the sham and tACS sessions. Also, the researchers in charge of analyzing the data did not know when each participant underwent the sham or tACS sessions, making this study double-blinded.
Co-first author Sangtae Ahn, PhD, a postdoc in Frohlich's lab, analyzed the data, which showed that Frohlich's team could indeed successfully target and enhance alpha oscillations in the somatosensory cortex of people with chronic lower back pain. When Prim and colleagues surveyed the participants, all of them reported a significant reduction in pain immediately following the tACS sessions, according to the subjective 0-10 pain scale. Remarkably, some participants reported feeling no pain after the tACS sessions. Participants did not report the same pain reduction after the sham stimulation sessions.
"The exciting thing is that these results occurred after just one session," Prim said. "We hope to conduct a larger study to discover the effects of multiple tACS sessions over a longer time period."
Frohlich said his lab also hopes to conduct studies on people with various kinds of chronic pain.
"This study is a perfect example of what's possible when scientists and clinicians collaborate," he said. "Ultimately, if we want to develop better treatments, cures, and prevention strategies, then these sorts of new approaches that bring researchers together are of fundamental importance."
Story Source:
Materials provided by University of North Carolina Health CareNote: Content may be edited for style and length.

Journal Reference:
  1. Sangtae Ahn, Julianna H. Prim, Morgan L. Alexander, Karen L. McCulloch, Flavio Fröhlich. Identifying and Engaging Neuronal Oscillations by Transcranial Alternating Current Stimulation in Patients with Chronic Low Back Pain: A Randomized, Crossover, Double-Blind, Sham-Controlled Pilot StudyThe Journal of Pain, 2018; DOI: 10.1016/j.jpain.2018.09.004

Thursday, November 15, 2018

Weightlifting is good for your heart and it doesn't take much

Lifting weights for less than an hour a week may reduce your risk for a heart attack or stroke by 40 to 70 percent, according to a new Iowa State University study. Spending more than an hour in the weight room did not yield any additional benefit, the researchers found.
"People may think they need to spend a lot of time lifting weights, but just two sets of bench presses that take less than 5 minutes could be effective," said DC (Duck-chul) Lee, associate professor of kinesiology.
The results -- some of the first to look at resistance exercise and cardiovascular disease -- show benefits of strength training are independent of running, walking or other aerobic activity. In other words, you do not have to meet the recommended guidelines for aerobic physical activity to lower your risk; weight training alone is enough. The study is published in Medicine and Science in Sports and Exercise.
Lee and his colleagues analyzed data of nearly 13,000 adults in the Aerobics Center Longitudinal Study. They measured three health outcomes: cardiovascular events such as heart attack and stroke that did not result in death, all cardiovascular events including death and any type of death. Lee says resistance exercise reduced the risk for all three.
"The results are encouraging, but will people make weightlifting part of their lifestyle? Will they do it and stick with it? That's the million-dollar question," Lee said.
Barriers to resistance training
The researchers recognize that unlike aerobic activity, resistance exercise is not as easy to incorporate into our daily routine. Lee says people can move more by walking or biking to the office or taking the steps, but there are few natural activities associated with lifting. And while people may have a treadmill or stationary bike at home, they likely do not have access to a variety of weight machines.
For these reasons, Lee says a gym membership may be beneficial. Not only does it offer more options for resistance exercise, but in a previous study Lee found people with a gym membership exercised more. While this latest study looked specifically at use of free weights and weight machines, Lee says people will still benefit from other resistance exercises or any muscle-strengthening activities.
"Lifting any weight that increases resistance on your muscles is the key," Lee said. "My muscle doesn't know the difference if I'm digging in the yard, carrying heavy shopping bags or lifting a dumbbell."
Other benefits of strength training
Much of the research on strength training has focused on bone health, physical function and quality of life in older adults. When it comes to reducing the risk for cardiovascular disease, most people think of running or other cardio activity. Lee says weight lifting is just as good for your heart, and there are other benefits.
Using the same dataset, Lee and his colleagues looked at the relationship between resistance exercise and diabetes as well as hypercholesterolemia, or high cholesterol. The two studies, published in Mayo Clinic Proceedings, found resistance exercise lowered the risk for both.
Less than an hour of weekly resistance exercise (compared with no resistance exercise) was associated with a 29 percent lower risk of developing metabolic syndrome, which increases risk of heart disease, stroke and diabetes. The risk of hypercholesterolemia was 32 percent lower. The results for both studies also were independent of aerobic exercise.
"Muscle is the power plant to burn calories. Building muscle helps move your joints and bones, but also there are metabolic benefits. I don't think this is well appreciated," Lee said. "If you build muscle, even if you're not aerobically active, you burn more energy because you have more muscle. This also helps prevent obesity and provide long-term benefits on various health outcomes."
Story Source:
Materials provided by Iowa State UniversityNote: Content may be edited for style and length.

Journal Reference:
  1. Yanghui Liu, Duck-chul Lee, Yehua Li, Weicheng Zhu, Riquan Zhang, Xuemei Sui, Carl J. Lavie, Steven N. Blair. Associations of Resistance Exercise with Cardiovascular Disease Morbidity and MortalityMedicine & Science in Sports & Exercise, 2018; 1 DOI: 

Drug combination makes cancer disappear in mice with neuroblastoma

Researchers investigating new treatments for neuroblastoma -- one of the most common childhood cancers -- have found that a combination of two drugs made tumours disappear in mice, making it more effective than any other drugs tested in these animals.
Professor Murray Norris, deputy director of the Children's Cancer Institute Australia for Medical Research, Sydney, Australia, told the 30th EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Dublin, Ireland, today (Thursday) that the findings were unusual and highly significant. But he warned that it would be some time before the drug combination would be tested in children and, if successful, made available more widely to treat children with this disease, even though both drugs are currently undergoing clinical trial in a range of adult cancers.
Neuroblastoma is one of the most common childhood cancers and is the leading single cause of cancer deaths in children under five. It is frequently found in the adrenal glands on top of the kidneys. Despite using intensive treatment regimens, children with the most aggressive forms of neuroblastoma have less than 50% survival rates.
Prof Norris said: "To study neuroblastoma in the laboratory, we use a genetically modified neuroblastoma mouse model that closely recapitulates clinical features of the disease, and these mice spontaneously develop neuroblastomas within weeks after birth. We have found that when we combined CBL0137 and panobinostat to treat mice bearing neuroblastomas, the tumours disappeared and never came back during the entire experiment, whereas the tumours continued to grow in mice that received either no treatment or only single drug treatment.
"This is a highly significant finding as this drug combination is the most effective therapy that we have observed in this neuroblastoma mouse model. It is unusual to see this effect, especially in these mice where neuroblastoma develops within seven weeks of birth and is aggressive in nature. In fact, the CBL0137/panobinostat combination is more effective than any other current clinical chemotherapy combinations that our laboratory has tested in these mice."
CBL0137, which belongs to a new class of drugs called curaxins, attacks the structure of cancer cells but is a safe drug that does not damage DNA in normal cells. Prof Norris and his colleagues used RNA sequencing technology that can detect drug-induced changes in tumours, to see how the combination of CBL0137 and panobinostat stopped neuroblastoma growing.
"Our results suggest that these drugs work through two different mechanisms that offer a two-pronged attack. One of these mechanisms appears to be a direct attack on the cancer cells themselves, killing them by inhibiting DNA repair; then a second mechanism is involved in inducing a robust immune response. This is very exciting and will hopefully facilitate the clinical development of effective and non-toxic therapies for childhood cancer," he said.
"Unlike conventional chemotherapy drugs that interact with DNA, CBL0137 is non-DNA damaging and therefore is comparatively less toxic. Developing CBL0137 combination therapies has the potential to reduce acute and long-term side effects and increase the quality of life of children with cancer while extending the survival rates of these children. Another important implication is that the CBL0137/panobinostat combination can activate an immune response which may significantly boost the efficacy of immunotherapy drugs that are otherwise ineffective for neuroblastoma."
The researchers are continuing their laboratory work to investigate further how the combination of these two drugs activates the immune response, and to test CBL0137/panobinostat with other immunotherapy drugs in mice. A phase I clinical trial of CBL0137 in children with neuroblastoma and other difficult-to-treat childhood cancers is planned to start in 2019, following the completion of a phase I clinical trial of the drug in adults with solid cancers and previously treated blood cancers. The trial of CBL0137 alone in children will need to be completed successfully before a trial testing the combination of the two drugs can be planned, which means it will be a few years before it is known whether the treatment can be used more widely.
Further lab research by Prof Norris and his colleagues also showed that CBL0137 and panobinostat slowed the growth of aggressive childhood leukaemias in mice and significantly extended survival.
In addition to approving CBL0137 for phase I clinical trials in adults, the FDA has already approved panobinostat for multiple myeloma and it is being tested in clinical trials for a range of other cancers.
Co-chair of the EORTC-NCI-AACR Symposium, Dr James L. Gulley, who is Director of the Medical Oncology Service at the NIH / NCI Center for Cancer Research in the USA, and who is an expert in cancer immunotherapy but was not involved in this research, commented: "Although these are results from work conducted in mice, they are very interesting and suggest the exciting possibility that this drug combination might work more effectively than single agents in children with this rare but aggressive tumour. These are patients who desperately need better treatments. We await the results of the clinical trials with interest."
[1] EORTC [European Organisation for Research and Treatment of Cancer, NCI [National Cancer Institute], AACR [American Association for Cancer Research].
Story Source:
Materials provided by ECCO-the European CanCer OrganisationNote: Content may be edited for style and length.

Tuesday, November 6, 2018

How To: Eat Like a Pro and lose weight, gain strength, look & feel fit

When you’re trying to stay healthy and shed a few extra pounds, it’s natural to start looking at your diet as a way to help you get in beach-ready shape and live longer. And so you should, since decades of research has shown what we eat on a daily basis can play a huge role in keeping us fit and out of the doctor’s office. But pinpointing the necessary dietary changes that need to be made can seem daunting, especially when there is no shortage of talking heads who claim to have the eating solutions you need. Let us help!
Instead of saying you need to treat gluten like it’s cyanide or banish dessert from your menu entirely, we’d prefer that you focus on a set of more sustainable and research-backed eating pursuits that are more effective in helping you achieve any fitness and health goals. Start with these 10 eating habits that will put you on the path to your best body ever.

Eat the Rainbow

If you’re in need of some alone time, head to the vegetable aisle of your supermarket. According to the Centers for Disease Control and Prevention, only 1 in 10 Americans are eating the recommended 2 to 3 cups of vegetables each day. In general, men fair worse than women when it comes to eating broccoli and carrots. As a result, we are missing out on the health-hiking, fat-torching fiber, vitamins, minerals and antioxidants that veggies supply. To get what you need, work at including a vegetable presence in most of your meals and snacks, and that can even include breakfast.
Tomatoes can easily sneak their way into scrambled eggs, and shredded carrots add natural sweetness to oatmeal. When grocery shopping, aim to toss a rainbow of vegetables into your cart — the pigments that give items like bell peppers, eggplant and spinach their colors have strong antioxidant activity with differing health benefits.

Go Fish for Fat

By now, most people have heard that omega-3 fats are beneficial and good for their hearts. But few, and we really mean few, people are heeding the advice to eat more of them. A recent study published in the journal Nutrients determined that about 98 percent of participants fell well below the optimum 8.0 Omega-3 Index — a test of omega-3 fat levels in the blood. American subjects clustered in the 3.25 to 5.75 range, a level where people won’t reap the full benefits of these mega-healthy fats, which includes warding off early mortality from various diseases.
The best way to raise your omega-3 index for better health is to reel in fatty fish for your meals at least twice per week. The main swimmers especially rich in omega-3s include salmon, sardines, mackerel, barramundi, sablefish (black cod), herring, rainbow trout, arctic char and some species of tuna. Shrimp, tilapia, cod and pollock (sold mostly as fish sticks and fried fish sandwiches) are popular seafood options in America but are omega-3 poor.

Spread It Out

If you spend several hours every week working up a serious sweat, make sure you spread out your calories throughout the day instead of packing most of them into dinner. In a watershed study published in the International Journal of Sports Nutrition and Metabolism, researchers found athletes who spent more time in a state of energy deficiency during a 24-hour period (in which their bodies were not obtaining enough calories to support training), experienced larger drops in metabolism and increased hormonal disturbances such as lower testosterone levels and higher levels of the stress hormone cortisol compared to their counterparts who spent fewer periods of the day in a calorie deficit. This is worrisome because it can hinder your ability to recover from workouts and build lean body mass.
Another study found that muscle protein synthesis was 25 percent higher among those who ate 30 grams of their protein at each meal — breakfast, lunch and dinner — than among those who consumed 10 grams in the morning, 15 grams at midday and 65 grams at night. Spreading out your protein intake gives your muscles a more consistent supply of amino acids to support recovery and growth.
The take-home message then — for improved fitness gains — is to better distribute your food intake throughout the day so you don’t leave your gas tank empty for too long.

Put Your Mind to It

Today, most people eat on autopilot, distracted by computer screens, smartphones or the need to wolf down a meal in a flash in order to get on with a never-ending list of tasks. But the perils of mindless eating are many: too much food eaten too fast, followed by belly bloat, pangs of guilt and a sense that you’ve just gleaned no joy from what you’ve eaten. Sound familiar?
This is why mindful eating is increasingly being promoted as a means to achieving a healthier relationship with the food we eat. With mindfulness, people are encouraged to tune into their thoughts, emotions and physical sensations during periods of eating as a means to making better food choices and recognizing signs of fullness to help limit gut-stretching overeating. Studies show that practicing mindful eating can help stamp out cravings for junk food, improve portion control of calorie-dense foods and reduce periods of emotional eating that can spiral into weight gain.
There are several ways to practice mindful eating, but some good ways to start include avoiding distractions like watching television while eating, eating more slowly to give you a better chance to recognize satiety signals, and halting the practice of serving foods like granola and yogurt straight from their containers so you can be more mindful of appropriate portion sizes. Take a moment before you reach for a snack to ponder how famished you actually are. Do so and you’re less likely to misinterpret sensations like tiredness or emotions such as anxiety as true hunger.

Vary Your Protein

It seems that as long as you eat enough protein, you’ve got a good chance of building muscle regardless of where you get it from. A recent study in The American Journal of Clinical Nutrition showed that among 2,986 men and women, muscle mass and strength were higher in those who consumed the most protein (1.8 grams per kilogram of bodyweight), compared to those who consumed the least (0.8 grams per kilogram of bodyweight). But an interesting finding was that the body composition and muscle strength results did not change based on people’s dietary protein preferences.
A person getting a large amount of his or her protein from meat was benefiting as much as a person gleaning a larger amount of protein from plant-based foods like beans. In fact, there are numerous benefits that come with achieving your daily protein quota from a variety of sources. Dairy can offer up leucine, an amino acid that is especially effective at stimulating muscle recovery and growth, plant proteins such as lentils offer up a bonus of antioxidants and fat-fighting fiber, beef contains important vitamins and minerals like iron and vitamin B12, and seafood can give you not only high-quality protein but also those much-needed omega-3 fats.
As they say, “Variety is the spice of life.”

Break the Sugar Habit

In America, life is sweet all right — so sweet that about 17 percent of the daily calories in the typical diet hail from added sugars — sugars like high-fructose corn syrup, cane sugar and even honey that don’t occur naturally in food. Eating an overly sweet diet not only contributes to Buddha belly but also to a range of health woes. For instance, researchers at the Centers for Disease Control and Prevention found that people who took in 10 to 24 percent of their daily calories from added sugar were 30 percent more likely to die from heart disease than those who consumed less.
A study in the journal Nature Communications suggests that sugar-heavy diets may stimulate the growth of cancer cells. And a report in The American Journal of Clinical Nutrition study revealed that high free-sugar intakes, considered to be sugars added to packaged foods like yogurt and cereal or to foods cooked at home, can coincide with lower intakes of several important micronutrients like calcium and magnesium.
So if you want to hone a six-pack and live a long retirement, it’s a good idea to make your diet less sweet. Beyond obvious methods such as nixing the sugar-sweetened drinks and sugary baked goods, you can go a long way in scaling back your intake of added sugars by carefully reading ingredient lists of everything from yogurt to salad dressing to nut butters to tomato sauce on the hunt for sweeteners that manufacturers have pumped into the product. Studies show that after a few repeated exposures, you can retrain your taste buds to enjoy versions that are less sweet.

Eat Bugs

There is a lot of love going around for bugs these days. No, not the ones buzzing around us while trying to enjoy a walk in the woods but instead the bugs that make up our gut microbiome — the collection of trillions of microbes or bacteria in the gastrointestinal tract that the white coats are increasingly linking to a dizzying array of health benefits that go well beyond better digestion.
A robust microbiome where beneficial microorganisms outnumber less desirable ones appears to play a role in everything from improved mood, trimmer waistlines and even improved immunity in people who exercise hard. To help fertilize your gut with more friendly critters, it’s a good idea to start including one or more servings of fermented foods into your diet each day. Options include yogurt (duh!), kefir, sauerkraut, miso, sourdough bread, tempeh, kimchi and low-sugar kombucha. So top your lunch sandwiches with sauerkraut or fiery kimchi, blend yogurt into postworkout shakes, and use crumbled tempeh as you would meat in dishes like chili and pasta sauce.

Go Whole

When you do eat your carbs, make them count by gravitating toward whole grains. A 2017 American Journal of Clinical Nutrition study randomly assigned men and women to two diets of equal calories for a six-week period — one that included whole grains and one that included refined grains — to determine whether there would be any differences in energy-metabolism metrics. In the end, it was discovered the whole-grain diet resulted in larger increases in resting metabolic rate and stool energy content that translated into nearly an extra 100 calories a day being lost.
Over a period of several weeks, this could translate into significant fat loss. Whole grains such as quinoa, oats, brown rice and whole-wheat pasta require more work for our digestive track to process than items like white bread and white rice, which can jack up our metabolic rates and lead to fewer of their calories being absorbed. Containing a bundle of vitamins, minerals, antioxidants and fiber, whole grains have also been linked to various improved health measures such as lower blood pressure numbers and better blood sugar control. The upshot is that at least 75 percent of the grains in your diet should hail from those that are whole instead of being processed to within an inch of their nutritional lives.

Booze Less

It’s fine to drink a beer or two while watching the game or enjoy a glass of wine during a nice dinner, but it’s wise to limit how much you imbibe overall. A study published in The Lancet involving nearly 600,000 current drinkers found that about 100 grams of alcohol — the equivalent of 5 pints of beer or five 175-milliliter glasses of wine — is the upper safe limit for consumption on a weekly basis. More than that raises the risk of early death from things like stroke and heart failure. More bad news for craft beer lovers: An investigation published in the Journal of Clinical Oncology cites evidence that alcohol consumption can increase the occurrence of certain cancers. Moderate (one daily drink for women and two for men) to heavy drinkers (eight or more drinks a week for women and 15 or more for men) face a two to five times higher risk for liver, mouth, throat, esophageal and colorectal cancers, the report warns.
And don’t forget that alcohol is generally considered a source of empty calories, which shuts down the body’s ability to burn fat, leading to beer bellies. It’s worth noting that alcohol drinking on the whole, including high-risk activities like binge drinking, is on the rise in America among all segments of the population. So for the sake of your health and waistline, don’t be ashamed to be a proud teetotaller and grab a nice big glass of water.

Don’t Eat too Clean

“Clean eating” is a buzz term these days and means feasting mostly on whole, unprocessed foods like grass-fed beef, legumes, vegetables, nuts and whole grains. For the most part, this is exactly the type of nutrient-dense eating we should be embracing. But trying to practice spick-and-span dieting too diligently by eating only cauliflower “rice” and sweet potato “toast” and you may find yourself charging the cookie jar headfirst. Being too restrictive with your diet by eliminating all indulgent foods could backfire and lead to massive cravings. Slam the door on pizza, ice cream and chips completely and you could very well end up feasting on larger portions of these items than if you just ate small amounts here and there to satisfy cravings.
You don’t want to make sugary or calorie-laden foods like brownies and fast-food burgers a daily treat, but a couple of small portions during the course of a week can be enough to get your fix without upending your get-lean pursuits. One way to do so is by occasionally adding a small amount of a splurge food to an otherwise nutritious plate of grub. A Vanderbilt University study found that this “vice-virtue bundle” can trick your brain into thinking that the overall healthy meal is just as delicious as a meal that is dominated by indulgent items like cheeseburgers, onion rings and cake. A little bit of a naughty taste can bring about enough satisfaction to keep your overall healthy diet on track.

Eat your vegetables (and fish): Another reason why they may promote heart health

Elevated levels of trimethylamine N-oxide (TMAO) -- a compound linked with the consumption of fish, seafood and a primarily vegetarian diet -- may reduce hypertension-related heart disease symptoms. New research in rats finds that low-dose treatment with TMAO reduced heart thickening (cardiac fibrosis) and markers of heart failure in an animal model of hypertension. The study is published ahead of print in the American Journal of Physiology -- Heart and Circulatory Physiology and was chosen as an APSselect article for November.
TMAO levels in the blood significantly increase after eating TMAO-rich food such as fish and vegetables. In addition, the liver produces TMAO from trimethylamine (TMA), a substance made by gut bacteria. The cause of high TMAO levels in the blood and the compound's effects on the heart and circulatory system are unclear, and earlier research has been contradictory. It was previously thought that TMAO blood plasma levels -- and heart disease risk -- rise after the consumption of red meat and eggs. However, "it seems that a fish-rich and vegetarian diet, which is beneficial or at least neutral for cardiovascular risk, is associated with a significantly higher plasma TMAO than red meat- and egg-rich diets, which are considered to increase the cardiovascular risk," researchers from the Medical University of Warsaw in Poland and the Polish Academy of Sciences wrote.
The researchers studied the effect of TMAO on rats that have a genetic tendency to develop high blood pressure (spontaneously hypertensive rats). One group of hypertensive rats was given low-dose TMAO supplements in their drinking water, and another group received plain water. They were compared to a control group of rats that does not have the same genetic predisposition and received plain water. The dosage of TMAO was designed to increase blood TMAO levels approximately four times higher than what the body normally produces. The rats were given TMAO therapy for either 12 weeks or 56 weeks and were assessed for heart and kidney damage and high blood pressure.
TMAO treatment did not affect the development of high blood pressure in any of the spontaneously hypertensive rats. However, condition of the animals given the compound was better than expected, even after more than a year of low-dose TMAO treatment. "A new finding of our study is that [a] four- to five-fold increase in plasma TMAO does not exert negative effects on the circulatory system. In contrast, a low-dose TMAO treatment is associated with reduced cardiac fibrosis and [markers of] failing heart in spontaneously hypertensive rats," the researchers wrote.
"Our study provides new evidence for a potential beneficial effect of a moderate increase in plasma TMAO on pressure-overloaded heart," the research team wrote. The researchers acknowledge that further study is needed to assess the effect of TMAO and TMA on the circulatory system. However, an indirect conclusion from the study could underscore the heart-healthy benefits of following a Mediterranean-style diet rich in fish and vegetables.
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Materials provided by American Physiological SocietyNote: Content may be edited for style and length.