by Michael Fuhrman, D.C.
The understanding of
broccoli’s health benefits has brought about a significant interest in
and subsequent research on the plant in recent years. The family of
compounds that have really grabbed the imagination of scientists is
called the glucosinolates. This group of substances, once consumed,
will, with the assistance of an enzyme called myrosinase, convert to a
new biologically active group of compounds called isothiocyanates. One
of them, sulforaphane, is the primary member of this group and has
received a significant amount of scientific attention.
Phase II detoxification
Perhaps the most clinically valuable role isothiocyanates, and specifically sulforaphane, play in the human body is their ability to stimulate phase II detoxification pathways in addition to cytochrome P450 enzymes. The P450 enzyme family acts, among other things, as catalysts for reactions involving the metabolism of many drugs, precancerous chemicals such as PCBs, and hormones including 17-beta estradiol. This mechanism of action, the activation of P450 enzymes, in addition to activating Nrf2, may perhaps be where sulforaphane displays its cancer-protective properties. Nrf2 is a transcription factor that, when activated, stimulates the body’s primary antioxidatve response pathway. This pathway is essential in reducing damage and protecting cells as well as DNA from toxin-generated reactive oxygen species, which can lay the groundwork for the genesis of cancer.
H. pylori
One property that many clinicians may not be aware of is sulforaphane’s ability to heal gastrointestinal mucosa damaged by H. pylori. H. pylori infections can generate a high amount of localized oxidative stress. This effect can be very damaging, greatly compromising the integrity of the GI tract’s epithelial lining. It is again sulforaphane’s antioxidative properties that act as tissue-protective agents, minimizing GI damage in those suffering with H. pylori. Additionally, broccoli sprouts high in sulforaphane were shown to help control and minimize H. pylori colonization as well.
Neuroprotection
Another application that was investigated through sulforaphane’s induction of the Nrf2 pathway was its ability to act as a neuroprotective agent. Spinal cord injuries can obviously be very traumatic with high post-injury levels of tissue-damaging inflammation, oxidation and antioxidant depletion being key factors in the resultant pathophysiology of the injury’s cascade. Researchers found that in animal models of contusive spinal cord injury, sulforaphane use holds potential as a therapeutic tool, as it was shown to help mitigate tissue damage through the activation of the Nrf2 pathway.
In one final reference to Nrf2, sulforaphane use was shown to suppress the accumulation of mercury in the brain (a major issue for individuals suffering with autism and ADHD for instance) in study animals exposed to methylmercury.
UV radiation
Exposure to excessive amounts of UV radiation is a continued health concern for many people, including clinicians. It can inflict its detrimental effects through lipid peroxidation, suppression of the immune response, and direct damage to vulnerable DNA, among others effects. Sulforaphane was shown to reduce damage to skin tissue, indicating its usefulness as a possible skin-protective compound.
Broccoli and its potent constituent sulforaphane can be powerful allies in helping to prevent disease. For those who have an aversion to the vegetable, perhaps broccoli sprouts or a daily dose of a sulforaphane-containing supplement can help protect us from some of the daily chemical toxic insults we all unfortunately encounter.
Phase II detoxification
Perhaps the most clinically valuable role isothiocyanates, and specifically sulforaphane, play in the human body is their ability to stimulate phase II detoxification pathways in addition to cytochrome P450 enzymes. The P450 enzyme family acts, among other things, as catalysts for reactions involving the metabolism of many drugs, precancerous chemicals such as PCBs, and hormones including 17-beta estradiol. This mechanism of action, the activation of P450 enzymes, in addition to activating Nrf2, may perhaps be where sulforaphane displays its cancer-protective properties. Nrf2 is a transcription factor that, when activated, stimulates the body’s primary antioxidatve response pathway. This pathway is essential in reducing damage and protecting cells as well as DNA from toxin-generated reactive oxygen species, which can lay the groundwork for the genesis of cancer.
H. pylori
One property that many clinicians may not be aware of is sulforaphane’s ability to heal gastrointestinal mucosa damaged by H. pylori. H. pylori infections can generate a high amount of localized oxidative stress. This effect can be very damaging, greatly compromising the integrity of the GI tract’s epithelial lining. It is again sulforaphane’s antioxidative properties that act as tissue-protective agents, minimizing GI damage in those suffering with H. pylori. Additionally, broccoli sprouts high in sulforaphane were shown to help control and minimize H. pylori colonization as well.
Neuroprotection
Another application that was investigated through sulforaphane’s induction of the Nrf2 pathway was its ability to act as a neuroprotective agent. Spinal cord injuries can obviously be very traumatic with high post-injury levels of tissue-damaging inflammation, oxidation and antioxidant depletion being key factors in the resultant pathophysiology of the injury’s cascade. Researchers found that in animal models of contusive spinal cord injury, sulforaphane use holds potential as a therapeutic tool, as it was shown to help mitigate tissue damage through the activation of the Nrf2 pathway.
In one final reference to Nrf2, sulforaphane use was shown to suppress the accumulation of mercury in the brain (a major issue for individuals suffering with autism and ADHD for instance) in study animals exposed to methylmercury.
UV radiation
Exposure to excessive amounts of UV radiation is a continued health concern for many people, including clinicians. It can inflict its detrimental effects through lipid peroxidation, suppression of the immune response, and direct damage to vulnerable DNA, among others effects. Sulforaphane was shown to reduce damage to skin tissue, indicating its usefulness as a possible skin-protective compound.
Broccoli and its potent constituent sulforaphane can be powerful allies in helping to prevent disease. For those who have an aversion to the vegetable, perhaps broccoli sprouts or a daily dose of a sulforaphane-containing supplement can help protect us from some of the daily chemical toxic insults we all unfortunately encounter.
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