Why Pot Makes You Eat and Eat and Eat

Endocannabinoids act directly on taste receptors on the tongue to enhance sweet taste according to the study.
“Our taste cells may be more involved in regulating our appetites than we had previously known,” said study author Robert Margolskee, M.D., Ph.D., a Monell molecular biologist. “Better understanding of the driving forces for eating and overeating could lead to interventions to stem the burgeoning rise in obesity and related diseases.”
Endocannabinoids are substances similar to THC, the active ingredient in marijuana. Endocannabinoids are produced in the brain and body and bind with cannabinoid receptors to help regulate appetite and many other processes involved in health and disease.
In the study, published online in the Proceedings of the National Academy of Sciences, the researchers conducted a series of experiments in mice to determine the behavioral, neural and cellular responses to sweet taste stimuli before and after the administration of endocannabinoids.
Sweet taste responses were enhanced by endocannabinoids in every case. Endocannibinoids had no effect on responses to sour, salty, bitter or umami taste stimuli.
The effects were abolished when the experiments were repeated using knockout mice lacking the CB1 cannabinoid receptor. Additional studies revealed that the CB1 receptor and the T1R3 sweet taste receptor are present in the same taste cells.
Together, the experiments demonstrate that endocannabinoids selectively enhance sweet taste by acting on tongue taste cells and that the effect is mediated by the endocannabinoid receptor.
“Modulation of sweet taste responses may be an important component of the endocannabinoid system’s role in regulating feeding behavior,” said Margolskee. He parenthetically noted that the well-known "marijuana munchies" may depend at least in part on endocannabinoid stimulation of tongue taste cells.
Sweet taste receptors also are found in the intestine and pancreas, where they help regulate nutrient absorption, insulin secretion and energy metabolism. If endocannibinoids also modulate the responses of pancreatic and intestinal sweet receptors, the findings may open doors to the development of novel therapeutic compounds to combat metabolic diseases such as obesity and diabetes.
The research was funded by grants from the Japan Society for the Promotion of Science and the National Institute on Deafness and Other Communication Disorders, National Institutes of Health.